Computational models in cardiology

SA Niederer, J Lumens, NA Trayanova - Nature reviews cardiology, 2019 - nature.com
The treatment of individual patients in cardiology practice increasingly relies on advanced
imaging, genetic screening and devices. As the amount of imaging and other diagnostic …

Molecular and cellular mechanisms of atrial fibrosis in atrial fibrillation

S Nattel - JACC: Clinical Electrophysiology, 2017 - jacc.org
Atrial fibrillation (AF) is the most common arrhythmia in clinical practice. Atrial fibrosis has
emerged as an important pathophysiological contributor and has been linked to AF …

Computationally guided personalized targeted ablation of persistent atrial fibrillation

PM Boyle, T Zghaib, S Zahid, RL Ali, D Deng… - Nature biomedical …, 2019 - nature.com
Atrial fibrillation (AF)—the most common arrhythmia—significantly increases the risk of
stroke and heart failure. Although catheter ablation can restore normal heart rhythms …

The clinical profile and pathophysiology of atrial fibrillation: relationships among clinical features, epidemiology, and mechanisms

J Andrade, P Khairy, D Dobrev, S Nattel - Circulation research, 2014 - Am Heart Assoc
Atrial fibrillation (AF) is the most common arrhythmia (estimated lifetime risk, 22%–26%). The
aim of this article is to review the clinical epidemiological features of AF and to relate them to …

Cardiac fibrosis in patients with atrial fibrillation: mechanisms and clinical implications

MS Dzeshka, GYH Lip, V Snezhitskiy… - Journal of the American …, 2015 - jacc.org
Atrial fibrillation (AF) is associated with structural, electrical, and contractile remodeling of
the atria. Development and progression of atrial fibrosis is the hallmark of structural …

Atrial remodeling and atrial fibrillation: recent advances and translational perspectives

S Nattel, M Harada - Journal of the American College of Cardiology, 2014 - jacc.org
Atrial fibrillation (AF) is the most common sustained arrhythmia in clinical practice. AF and its
complications are responsible for important population morbidity and mortality. Presently …

Cellular and molecular electrophysiology of atrial fibrillation initiation, maintenance, and progression

J Heijman, N Voigt, S Nattel, D Dobrev - Circulation research, 2014 - Am Heart Assoc
Atrial fibrillation (AF) is the most common clinically relevant arrhythmia and is associated
with increased morbidity and mortality. The incidence of AF is expected to continue to rise …

Patient-derived models link re-entrant driver localization in atrial fibrillation to fibrosis spatial pattern

S Zahid, H Cochet, PM Boyle, EL Schwarz… - Cardiovascular …, 2016 - academic.oup.com
Aims The mechanisms underlying persistent atrial fibrillation (AF) in patients with atrial
fibrosis are poorly understood. The goal of this study was to use patient-derived atrial …

Efficacy of left atrial voltage‐based catheter ablation of persistent atrial fibrillation

T Yamaguchi, T Tsuchiya, S Nakahara… - Journal of …, 2016 - Wiley Online Library
Low Voltage‐Based Ablation for Atrial Fibrillation Background Low‐voltage zones (LVZs)
represent fibrotic tissue and are substrates for atrial fibrillation (AF). We hypothesized that …

[HTML][HTML] Computational modeling of cardiac electrophysiology and arrhythmogenesis: toward clinical translation

NA Trayanova, A Lyon, J Shade… - Physiological …, 2023 - pmc.ncbi.nlm.nih.gov
The complexity of cardiac electrophysiology, involving dynamic changes in numerous
components across multiple spatial (from ion channel to organ) and temporal (from …