BACE1 inhibitors: Current status and future directions in treating Alzheimer's disease
Alzheimer's disease (AD) is an irreversible, progressive neurodegenerative brain disorder
with no current cure. One of the important therapeutic approaches of AD is the inhibition of β …
with no current cure. One of the important therapeutic approaches of AD is the inhibition of β …
Recent developments in new therapeutic agents against Alzheimer and Parkinson diseases: in-silico approaches
Neurodegenerative diseases (ND), including Alzheimer's (AD) and Parkinson's Disease
(PD), are becoming increasingly more common and are recognized as a social problem in …
(PD), are becoming increasingly more common and are recognized as a social problem in …
β-Secretase as a Primary Drug Target of Alzheimer Disease: Function, Structure, and Inhibition
S Verma, D Paramanick - Deciphering Drug Targets for Alzheimer's …, 2023 - Springer
Abstract β-secretase (BACE1) is responsible for regulating different biological functions.
Several biochemical studies reported that BACE1 enzyme plays a key role in Alzheimer …
Several biochemical studies reported that BACE1 enzyme plays a key role in Alzheimer …
Population density analysis for determining the protonation state of the catalytic dyad in BACE1-tertiary carbinamine-based inhibitor complex
C Gueto-Tettay, L Pelaez-Bedoya… - Journal of …, 2018 - Taylor & Francis
BACE1 is an aspartyl protease with a very relevant role in medicinal chemistry related to
Alzheimer Disease since it has demonstrated to be a promising therapeutic target for …
Alzheimer Disease since it has demonstrated to be a promising therapeutic target for …
G-score: A function to solve the puzzle of modeling the protonation states of β-secretase binding pocket
The population density concept has emerged as a proposal for the analysis of molecular
dynamics results, the key characteristic of population density is the evaluation of the …
dynamics results, the key characteristic of population density is the evaluation of the …
Avaliação por bioquímica quântica de interações entre o receptor beta secretase 1 (BACE1) e Ligantes
WS Clemente Júnior - 2021 - bdtd.ibict.br
A doença de Alzheimer (DA) é um transtorno neurodegenerativo multifatorial progressivo e
a principal causa de demência na vida adulta tardia. A hipótese da cascata amiloide sugere …
a principal causa de demência na vida adulta tardia. A hipótese da cascata amiloide sugere …