The structural and functional integrity of the brain depends on the delicate balance between
substrate delivery through blood flow and energy demands imposed by neural activity …

The AP-1 transcription factor is mainly composed of Jun, Fos and ATF protein dimers. It
mediates gene regulation in response to a plethora of physiological and pathological stimuli …

Autophagy is an important cellular self-digestion and recycling pathway that helps in
maintaining cellular homeostasis. Dysregulation at various steps of the autophagic and …

Neurodegenerative diseases (NDs) are currently incurable diseases that cause progressive
degeneration of nerve cells. Many of the disease-causing proteins of NDs are “undruggable” …

Despite our present knowledge of some of the cellular pathways that modulate central
nervous system injury, complete therapeutic prevention or reversal of acute or chronic …

The primary physiological function of mitochondria is to generate adenosine triphosphate
through oxidative phosphorylation via the electron transport chain. Overproduction of …

Neurons may die as a normal physiological process during development or as a
pathological process in diseases. The best-understood mechanism of neuronal cell death is …

The nuclear transcription factor AP-1, composed of dimers of Fos and Jun proteins, has
been linked to a startling breadth of cellular events including cell transformation …

It has been postulated that the development of amyloid plaques in Alzheimer's disease (AD)
may result from an imbalance between the generation and clearance of the amyloid-β …

Dysfunction of the microRNA (miR) network has been emerging as a major regulator in
neurological diseases. However, little is known about the functional significance of unique …