952 STRYNADKA & JAMES jected to high-resolution crystal structure analyses fall into two
general categories (Table 1). One group includes many extracellular enzymes and proteins …

The calcium binding proteins of the EF-hand super-family are involved in the regulation of all
aspects of cell function. These proteins exhibit a great diversity of composition, structure …

The solvent-accessible surface area (A s) of 46 monomeric proteins is calculated using
atomic co-ordinates from high-resolution and well-refined crystal structures. The A s of these …

Nuclear magnetic resonance (NMR) is widely used across many fields of science because
of the rich data it produces, and some of the most valuable data come from studies of …

The three-dimensional structure of calmodulin has been determined crystallographically at
3.0 Å resolution. The molecule consists of two globular lobes connected by a long exposed …

Publisher Summary The chapter presents a procedure that is applicable to single
isomorphous replacement (SIR) data without anomalous scattering information as well as to …

A new method of comparing protein structures is described, based on distance plot analysis.
It is relatively insensitive to insertions and deletions in sequence and is tolerant of the …

The crystal structure of porcine pancreatic alpha‐amylase (PPA) has been solved at 2.9 A
resolution by X‐ray crystallographic methods. The enzyme contains three domains. The …

The question of how the amino acid sequence of a protein specifies its three-dimensional
structure remains to be answered. Proteins are so large and complex that it is difficult to …

Publisher Summary Calmodulin is the major intracellular, and intramembrane, Ca 2+
receptor. Its function is to detect free Ca 2+ and translate changes in Ca 2+ concentrations …