Early cancer detection based on exosome biosensors in biological samples

R Uyar, G Özçelikay-Akyıldız, Sİ Kaya, SB Nergis… - Sensors and Actuators B …, 2024 - Elsevier
Produced by all cells and found in all body fluids, exosomes differ in their content such as
lipid, nucleic acid and protein that can facilitate tumor growth. Exosomes, which carry …

miRNAs in pancreatic cancer progression and metastasis

ETY Mok, JL Chitty, TR Cox - Clinical & Experimental Metastasis, 2024 - Springer
Small non-coding RNA or microRNA (miRNA) are critical regulators of eukaryotic cells.
Dysregulation of miRNA expression and function has been linked to a variety of diseases …

Exosomal miRNA biomarker panel for pancreatic ductal adenocarcinoma detection in patient plasma: a pilot study

A Makler, W Asghar - International Journal of Molecular Sciences, 2023 - mdpi.com
Pancreatic ductal adenocarcinoma (PDAC) is rapidly becoming one of the leading causes of
cancer-related deaths in the United States, and with its high mortality rate, there is a …

Liquid biopsies and exosomal ncRNA: Transforming pancreatic cancer diagnostics and therapeutics

AK Balaraman, E Moglad, M Afzal, MA Babu, K Goyal… - Clinica Chimica …, 2024 - Elsevier
Pancreatic cancer is a highly fatal malignancy due to poor early detection rate and
resistance to conventional therapies. This review examines the potential for liquid biopsy as …

Development of a microfluidic device for exosome isolation in point-of-care settings

N Ramnauth, E Neubarth, A Makler-Disatham, M Sher… - Sensors, 2023 - mdpi.com
Exosomes have gained recognition in cancer diagnostics and therapeutics. However, most
exosome isolation methods are time-consuming, costly, and require bulky equipment …

Emerging Therapeutic Options in Pancreatic Cancer Management

D Delle Cave - International Journal of Molecular Sciences, 2024 - mdpi.com
Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with a 5-year survival
rate of< 8%[1–3]. PDAC is characterized by dense desmoplastic stroma, which can …

[HTML][HTML] Emerging Horizons in the Diagnosis of Pancreatic Cancer: The Role of Circulating microRNAs as Early Detection Biomarkers for Pancreatic Ductal …

I Reyaz, B Khan, N James, H Azhar, A Rehman… - Cureus, 2024 - ncbi.nlm.nih.gov
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer with a poor
prognosis, primarily due to a late diagnosis. Recent studies have focused on identifying non …

Expression of miR-425-5p in pancreatic carcinoma and its correlation with tumor immune microenvironment

S Jian, D Kong, J Tian - Journal of Investigative Surgery, 2023 - Taylor & Francis
Background: Pancreatic carcinoma (PC) is a global health threat with a high death rate.
miRNAs are implicated in tumor initiation and progression. This study explored the …

[HTML][HTML] Development of liquid biopsy in detection and screening of pancreatic cancer

X Chen, X Hu, T Liu - Frontiers in Oncology, 2024 - ncbi.nlm.nih.gov
Pancreatic cancer is a highly lethal malignant tumor, which has the characteristics of occult
onset, low early diagnosis rate, rapid development and poor prognosis. The reason for the …

Current understanding of therapeutic and diagnostic applications of exosomes in pancreatic cancer

N Shakerian, A Tafazoli, A Razavinia, ZS Aghajani… - Pancreas, 2024 - journals.lww.com
Unusual symptoms, rapid progression, lack of reliable early diagnostic biomarkers, and lack
of efficient treatment choices are the ongoing challenges of pancreatic cancer. Numerous …