Degeneration of central cholinergic neurons impairs memory, and enhancement of
cholinergic synapses improves cognitive processes. Cholinergic signaling is also anti …

The physiological regulation of the immune system encompasses comprehensive anti‐
inflammatory mechanisms that can be harnessed for the treatment of infectious and …

The nicotinic acetylcholine receptor (nAChR) belongs to a superfamily of pentameric ligand-
gated ion channels involved in many physiologic and pathologic processes. Among …

Summary 1 Muscarinic M1–M5 receptors mediate the metabotropic actions of acetylcholine
in the nervous system. A growing body of data indicate they also mediate autocrine functions …

Delirium, or acute brain dysfunction, is a life-threatening global disturbance in cognitive
functioning that frequently manifests in critically ill patients. This review examines the current …

The parasympathetic neurotransmitter acetylcholine is also synthesised and secreted by
non-neuronal cells and modifies their behaviour. This is termed the “non-neuronal …

The cholinergic nervous system attenuates the production of pro‐inflammatory cytokines
and inhibits inflammatory processes. Hence, in animal models of intestinal inflammation …

Nicotine, the major component of cigarettes, has demonstrated conflicting impact on the
immune system: some authors suggest that increases pro-inflammatory cytokines and …

Reciprocal interactions between glia and neurons are essential for many critical functions in
brain health and disease. Microglial cells, the brain resident macrophages, and astrocytes …

γ-Amino butyric acid (GABA) is an ubiquitous neurotransmitter in the central nervous system
and it is also present in non-neuronal cells. In this study we investigated the presence of …