Primary cilia, antenna-like sensory organelles protruding from the surface of most vertebrate
cell types, are essential for regulating signalling pathways during development and adult …

For complex diseases, most drugs are highly ineffective, and the success rate of drug
discovery is in constant decline. While low quality, reproducibility issues, and translational …

Cancer is a disease of uncontrollably reproducing cells. It is governed by biochemical
pathways that have escaped the regulatory bounds of normal homeostatic balance. This …

G protein-coupled receptors (GPCRs) relay extracellular stimuli into specific cellular
functions. Cells express many different GPCRs, but all these GPCRs signal to only a few …

The fidelity of intracellular signaling hinges on the organization of dynamic activity
architectures. Spatial compartmentation was first proposed over 30 years ago to explain how …

Cell signaling is a complex process. The faithful transduction of information into specific
cellular actions depends on the synergistic effects of many regulatory molecules, nurtured by …

Cells interpret a variety of signals through G-protein-coupled receptors (GPCRs) and
stimulate the generation of second messengers such as cyclic adenosine monophosphate …

G protein–coupled receptors are the largest and pharmacologically most important receptor
family and are involved in the regulation of most cell functions. Most of them reside …

The parathyroid hormone (PTH) type 1 receptor (PTHR) is a class BG protein–coupled
receptor (GPCR) that regulates mineral ion, vitamin D, and bone homeostasis. Activation of …

Liquid–liquid phase separation (LLPS) is emerging as a mechanism of spatiotemporal
regulation that could answer long-standing questions about how order is achieved in …