Structure-function relationships among RNA-dependent RNA polymerases
RNA-dependent RNA polymerases (RdRPs) play key roles in viral transcription and genome
replication, as well as epigenetic and post-transcriptional control of cellular gene …
replication, as well as epigenetic and post-transcriptional control of cellular gene …
Closing the circle: replicating RNA with RNA
LKL Cheng, PJ Unrau - Cold Spring Harbor perspectives …, 2010 - cshperspectives.cshlp.org
How life emerged on this planet is one of the most important and fundamental questions of
science. Although nearly all details concerning our origins have been lost in the depths of …
science. Although nearly all details concerning our origins have been lost in the depths of …
The structure of a birnavirus polymerase reveals a distinct active site topology
Single-subunit polymerases are universally encoded in both cellular organisms and viruses.
Their three-dimensional structures have the shape of a right-hand with the active site located …
Their three-dimensional structures have the shape of a right-hand with the active site located …
Identification of cis-acting elements in the 3′-untranslated region of the dengue virus type 2 RNA that modulate translation and replication
M Manzano, ED Reichert, S Polo, B Falgout… - Journal of Biological …, 2011 - ASBMB
Using the massively parallel genetic algorithm for RNA folding, we show that the core region
of the 3′-untranslated region of the dengue virus (DENV) RNA can form two dumbbell …
of the 3′-untranslated region of the dengue virus (DENV) RNA can form two dumbbell …
The respiratory syncytial virus polymerase has multiple RNA synthesis activities at the promoter
SL Noton, LR Deflubé, CZ Tremaglio, R Fearns - 2012 - journals.plos.org
Respiratory syncytial virus (RSV) is an RNA virus in the Family Paramyxoviridae. Here, the
activities performed by the RSV polymerase when it encounters the viral antigenomic …
activities performed by the RSV polymerase when it encounters the viral antigenomic …
Initiation of RNA polymerization and polymerase encapsidation by a small dsRNA virus
During the replication cycle of double-stranded (ds) RNA viruses, the viral RNA-dependent
RNA polymerase (RdRP) replicates and transcribes the viral genome from within the viral …
RNA polymerase (RdRP) replicates and transcribes the viral genome from within the viral …
Replication of the hepatitis delta virus RNA genome
JM Taylor - Advances in virus research, 2009 - Elsevier
Hepatitis delta virus (HDV) is a subviral agent dependent upon hepatitis B virus (HBV). HDV
uses the envelope proteins of HBV to achieve assembly and infection of target cells …
uses the envelope proteins of HBV to achieve assembly and infection of target cells …
Primer-Dependent and Primer-Independent Initiation of Double Stranded RNA Synthesis by Purified Arabidopsis RNA-Dependent RNA Polymerases RDR2 and …
A Devert, N Fabre, M Floris, B Canard, C Robaglia… - PLoS …, 2015 - journals.plos.org
Cellular RNA-dependent RNA polymerases (RDRs) are fundamental components of RNA
silencing in plants and many other eukaryotes. In Arabidopsis thaliana genetic studies have …
silencing in plants and many other eukaryotes. In Arabidopsis thaliana genetic studies have …
Structure and function of RNA replication
J Ortín, F Parra - Annu. Rev. Microbiol., 2006 - annualreviews.org
Contrary to their host cells, many viruses contain RNA as genetic material and hence
encode an RNA-dependent RNA polymerase to replicate their genomes. This review …
encode an RNA-dependent RNA polymerase to replicate their genomes. This review …
Structural explanation for the role of Mn2+ in the activity of ϕ6 RNA-dependent RNA polymerase
The biological role of manganese (Mn2+) has been a long-standing puzzle, since at low
concentrations it activates several polymerases whilst at higher concentrations it inhibits …
concentrations it activates several polymerases whilst at higher concentrations it inhibits …