Chemical ecology of antibiotic production by actinomycetes

A Van der Meij, SF Worsley… - FEMS microbiology …, 2017 - academic.oup.com
Actinomycetes are a diverse family of filamentous bacteria that produce a plethora of natural
products relevant for agriculture, biotechnology and medicine, including the majority of the …

The Pho regulon: a huge regulatory network in bacteria

F Santos-Beneit - Frontiers in microbiology, 2015 - frontiersin.org
One of the most important achievements of bacteria is its capability to adapt to the changing
conditions of the environment. The competition for nutrients with other microorganisms …

Molecular regulation of antibiotic biosynthesis in Streptomyces

G Liu, KF Chater, G Chandra, G Niu… - … and molecular biology …, 2013 - Am Soc Microbiol
Streptomycetes are the most abundant source of antibiotics. Typically, each species
produces several antibiotics, with the profile being species specific. Streptomyces coelicolor …

Regulation of antibiotic production in Actinobacteria: new perspectives from the post-genomic era

HU Van Der Heul, BL Bilyk, KJ McDowall… - Natural product …, 2018 - pubs.rsc.org
Covering: 2000 to 2018 The antimicrobial activity of many of their natural products has
brought prominence to the Streptomycetaceae, a family of Gram-positive bacteria that …

The regulation of the secondary metabolism of Streptomyces: new links and experimental advances

GP Van Wezel, KJ McDowall - Natural product reports, 2011 - pubs.rsc.org
Covering: up to early 2011 Streptomycetes and other actinobacteria are renowned as a rich
source of natural products of clinical, agricultural and biotechnological value. They are being …

Characterization of a New GlnR Binding Box in the Promoter of amtB in Streptomyces coelicolor Inferred a PhoP/GlnR Competitive Binding Mechanism for Transcriptional …

Y Wang, XF Cen, GP Zhao, J Wang - Journal of bacteriology, 2012 - Am Soc Microbiol
The transcription of amtB in Streptomyces coelicolor has been proposed to be counter-
regulated by GlnR (a global regulator for nitrogen metabolism) and PhoP (a global regulator …

Towards a new science of secondary metabolism

A Craney, S Ahmed, J Nodwell - The Journal of antibiotics, 2013 - nature.com
Secondary metabolites are a reliable and very important source of medicinal compounds.
While these molecules have been mined extensively, genome sequencing has suggested …

Building a highly efficient Streptomyces super-chassis for secondary metabolite production by reprogramming naturally-evolved multifaceted shifts

S Qiu, B Yang, Z Li, S Li, H Yan, Z **n, J Liu, X Zhao… - Metabolic …, 2024 - Elsevier
Streptomyces has an extensive array of bioactive secondary metabolites (SMs).
Nevertheless, devising a framework for the heterologous production of these SMs remains …

Identification of two‐component system AfsQ1/Q2 regulon and its cross‐regulation with GlnR in Streptomyces coelicolor

R Wang, Y Mast, J Wang, W Zhang… - Molecular …, 2013 - Wiley Online Library
The two‐component system AfsQ1/Q2 of S treptomyces coelicolor was identified in our
previous work as a pleiotropic regulator for antibiotic biosynthesis and morphological …

Two-Component Systems of Streptomyces coelicolor: An Intricate Network to Be Unraveled

R Sánchez de la Nieta, RI Santamaría… - International Journal of …, 2022 - mdpi.com
Bacteria of the Streptomyces genus constitute an authentic biotech gold mine thanks to their
ability to produce a myriad of compounds and enzymes of great interest at various clinical …