Highlights•3 waves of innovation have enhanced protein production in CHO cells.•Systems-
level methods are now unravelling drivers of protein production.•Predictive models will …

Determining protein levels in each tissue and how they compare with RNA levels is
important for understanding human biology and disease as well as regulatory processes …

Cellular senescence is implicated in a wide range of physiological and pathological
conditions throughout an organism's entire lifetime. In particular, it has become evident that …

Abstract In mammalian cells,> 25% of synthesized proteins are exported through the
secretory pathway. The pathway complexity, however, obfuscates its impact on the secretion …

Galleria mellonella is a pest of honeybees in many countries because its larvae feed on
beeswax. However, G. mellonella larvae can also eat various plastics, including …

The collection of proteins secreted from a cell—the secretome—is of particular interest in
cancer pathophysiology due to its diagnostic potential and role in tumorigenesis. However …

Biologics represent the fastest growing group of therapeutics, but many advanced
recombinant protein moieties remain difficult to produce. Here, we identify metabolic …

Although radiotherapy is given to more than 50% of cancer patients, little progress has been
made in identifying optimal radiotherapy-drug combinations to improve treatment efficacy …

Non-small cell lung cancer (NSCLC) is the deadliest form of cancer worldwide, due in part to
its proclivity to metastasize. Identifying novel drivers of invasion and metastasis holds …

Recombinant protein production can cause severe stress on cellular metabolism, resulting
in limited titer and product quality. To investigate cellular and metabolic characteristics …