Fifty years since the first description of an association between HLA and human disease,
HLA molecules have proven to be central to physiology, protective immunity and …

Allogeneic hematopoietic cell transplantation involves consideration of both donor and
recipient characteristics to guide the selection of a suitable graft. Sufficient high-resolution …

Human leukocyte antigen (HLA) can recognize and bind foreign peptides to present them to
specialized immune cells, then initiate an immune response. Computational prediction of the …

Prediction of HLA epitopes is important for the development of cancer immunotherapies and
vaccines. However, current prediction algorithms have limited predictive power, in part …

To establish a healthy pregnancy, maternal immune cells must tolerate fetal allo-antigens
and remain competent to respond to infections both systemically and in placental tissues …

We report detailed peptide‐binding affinities between 438 HLA Class I and Class II proteins
and complete proteomes of seven pandemic human viruses, including coronaviruses …

Variations of human leukocyte antigen (HLA) genes in the major histocompatibility complex
region (MHC) significantly affect the risk of various diseases, especially autoimmune …

The T cell receptor (TCR) repertoire encodes immune exposure history through the dynamic
formation of immunological memory. Statistical analysis of repertoire sequencing data has …

In comparison with the major histocompatibility complexes (MHCs) of typical mammals, the
chicken MHC is simple and compact with a single dominantly expressed class I molecule …

Immune response to disease requires coordinated expression of an army of molecules. The
highly polymorphic MHC class I and class II molecules are key to control of specificity of …