Coupling between bone formation and bone resorption refers to the process within basic
multicellular units in which resorption by osteoclasts is met by the generation of osteoblasts …

As the only cells definitively shown to degrade bone, osteoclasts are key mediators of
skeletal diseases including osteoporosis. Bone-forming osteoblasts, and hematopoietic and …

Bone remodeling is a tightly regulated process securing repair of microdamage (targeted
remodeling) and replacement of old bone with new bone through sequential osteoclastic …

Cathepsin K is a cysteine protease member of the cathepsin lysosomal protease family.
Although cathepsin K is highly expressed in osteoclasts, lower levels of cathepsin K are also …

The adult skeleton regenerates by temporary cellular structures that comprise teams of
juxtaposed osteoclasts and osteoblasts and replace periodically old bone with new. A …

Proper bone remodeling necessarily requires that osteoblasts reconstruct the bone that
osteoclasts have resorbed. However, the cellular events connecting resorption to …

The bone remodelling cycle (see Poster panel “The bone remodelling cycle”) maintains the
integrity of the skeleton through the balanced activities of its constituent cell types. These are …

Cells in osteoclast and osteoblast lineages communicate with each other through cell–cell
contact, diffusible paracrine factors and cell–bone matrix interaction. Osteoclast–osteoblast …

Under most conditions, resorbed bone is nearly precisely replaced in location and amount
by new bone. Thus, it has long been recognized that bone loss through osteoclast-mediated …

Monocytes and macrophages are innate immune cells with diverse functions ranging from
phagocytosis of microorganisms to forming a bridge with the adaptive immune system. A …