Cytoplasmic dynein 1 is an important microtubule-based motor in many eukaryotic cells.
Dynein has critical roles both in interphase and during cell division. Here, we focus on …

The active transport of organelles and other cargos along the axon is required to maintain
neuronal health and function, but we are just beginning to understand the complex …

Axonal transport is the process whereby motor proteins actively navigate microtubules to
deliver diverse cargoes, such as organelles, from one end of the axon to the other, and is …

Neurons are markedly compartmentalized, which makes them reliant on axonal transport to
maintain their health. Axonal transport is important for anterograde delivery of newly …

BACKGROUND Neurons are polarized cells with extreme geometries. Multiple dendrites
and one axon generally emerge from a single cell body and establish synaptic contacts with …

Microtubule (MT)–associated protein 7 (MAP7) is a required cofactor for kinesin-1–driven
transport of intracellular cargoes. Using cryo–electron microscopy and single–molecule …

Cytoplasmic dynein is a microtubule motor that is activated by its cofactor dynactin and a
coiled-coil cargo adaptor,–. Up to two dynein dimers can be recruited per dynactin, and …

Mitochondria are transported along microtubules by opposing kinesin and dynein motors.
Kinesin-1 and dynein-dynactin are linked to mitochondria by TRAK proteins, but it is unclear …

Dynein and its cofactor dynactin form a highly processive microtubule motor in the presence
of an activating adaptor, such as BICD2. Different adaptors link dynein and dynactin to …

In motile cilia, a mechanoregulatory network is responsible for converting the action of
thousands of dynein motors bound to doublet microtubules into a single propulsive …