The G protein-coupled oestrogen receptor GPER in health and disease: an update
Oestrogens and their receptors contribute broadly to physiology and diseases. In
premenopausal women, endogenous oestrogens protect against cardiovascular, metabolic …
premenopausal women, endogenous oestrogens protect against cardiovascular, metabolic …
The G-protein-coupled estrogen receptor GPER in health and disease
Estrogens mediate profound effects throughout the body and regulate physiological and
pathological processes in both women and men. The low prevalence of many diseases in …
pathological processes in both women and men. The low prevalence of many diseases in …
Twenty years of the G protein-coupled estrogen receptor GPER: Historical and personal perspectives
Estrogens play a critical role in many aspects of physiology, particularly female reproductive
function, but also in pathophysiology, and are associated with protection from numerous …
function, but also in pathophysiology, and are associated with protection from numerous …
Crosstalk between Notch, HIF-1α and GPER in breast cancer EMT
The Notch signaling pathway acts in both physiological and pathological conditions,
including embryonic development and tumorigenesis. In cancer progression, diverse …
including embryonic development and tumorigenesis. In cancer progression, diverse …
HIF-1α/GPER signaling mediates the expression of VEGF induced by hypoxia in breast cancer associated fibroblasts (CAFs)
Abstract Introduction Carcinoma-associated fibroblasts (CAFs) play a pivotal role in cancer
progression by contributing to invasion, metastasis and angiogenesis. Solid tumors possess …
progression by contributing to invasion, metastasis and angiogenesis. Solid tumors possess …
G protein-coupled estrogen receptor: a potential therapeutic target in cancer
S Xu, S Yu, D Dong, LTO Lee - Frontiers in endocrinology, 2019 - frontiersin.org
The G protein-coupled estrogen receptor (GPER) is a seven-transmembrane-domain
receptor that mediates non-genomic estrogen related signaling. After ligand activation …
receptor that mediates non-genomic estrogen related signaling. After ligand activation …
The IL1β-IL1R signaling is involved in the stimulatory effects triggered by hypoxia in breast cancer cells and cancer-associated fibroblasts (CAFs)
Background Hypoxia plays a relevant role in tumor-related inflammation toward the
metastatic spread and cancer aggressiveness. The pro-inflammatory cytokine interleukin-1β …
metastatic spread and cancer aggressiveness. The pro-inflammatory cytokine interleukin-1β …
[HTML][HTML] Copper activates HIF-1α/GPER/VEGF signalling in cancer cells
Copper promotes tumor angiogenesis, nevertheless the mechanisms involved remain to be
fully understood. We have recently demonstrated that the G-protein estrogen receptor …
fully understood. We have recently demonstrated that the G-protein estrogen receptor …
[HTML][HTML] GPER-novel membrane estrogen receptor
MA Zimmerman, RA Budish, S Kashyap… - Clinical science …, 2016 - ncbi.nlm.nih.gov
The recent discovery of the G protein-coupled estrogen receptor (GPER) presents new
challenges and opportunities for understanding the physiology, pathophysiology, and …
challenges and opportunities for understanding the physiology, pathophysiology, and …
The G protein-coupled estrogen receptor GPER/GPR30 as a regulator of cardiovascular function
Endogenous estrogens are important regulators of cardiovascular homeostasis in
premenopausal women and delay the development of hypertension and coronary artery …
premenopausal women and delay the development of hypertension and coronary artery …