MET‐activating ubiquitin multimers

N Kawakami, H Sato, N Terasaka… - Angewandte …, 2023 - Wiley Online Library
Receptor tyrosine kinases (RTKs) are generally activated through their dimerization and/or
oligomerization induced by their cognate ligands, and one such RTK hepatocyte growth …

Strategies for optimizing recombinant protein synthesis in plant cells: classical approaches and new directions

SM Rozov, EV Deineko - Molecular biology, 2019 - Springer
At present, pharmacologically significant proteins are synthesized in different expression
systems, from bacterial to mammalian and insect cell cultures. The plant expression systems …

Circadian networks in human embryonic stem cell‐derived cardiomyocytes

P Dierickx, MW Vermunt, MJ Muraro, MP Creyghton… - EMBO …, 2017 - embopress.org
Cell‐autonomous circadian oscillations strongly influence tissue physiology and
pathophysiology of peripheral organs including the heart, in which the circadian clock is …

Optimization of genome knock-in method: Search for the most efficient genome regions for transgene expression in plants

SM Rozov, NV Permyakova, YV Sidorchuk… - International Journal of …, 2022 - mdpi.com
Plant expression systems are currently regarded as promising alternative platforms for the
production of recombinant proteins, including the proteins for biopharmaceutical purposes …

Meta-analysis of human gene expression in response to Mycobacterium tuberculosis infection reveals potential therapeutic targets

Z Wang, S Arat, M Magid-Slav, JR Brown - BMC systems biology, 2018 - Springer
Background With the global emergence of multi-drug resistant strains of Mycobacterium
tuberculosis, new strategies to treat tuberculosis are urgently needed such as therapeutics …

Dynamic transcription of ubiquitin genes under basal and stressful conditions and new insights into the multiple UBC transcript variants

M Bianchi, E Giacomini, R Crinelli, L Radici, E Carloni… - Gene, 2015 - Elsevier
Ubiquitin (Ub) is a small 76-amino acid protein that is engaged in many different pathways
within the cell, including protein turnover. During proteotoxic stress, when the demand of …

Induction of ubiquitin C (UBC) gene transcription is mediated by HSF1: role of proteotoxic and oxidative stress

M Bianchi, R Crinelli, V Arbore, M Magnani - FEBS Open Bio, 2018 - Wiley Online Library
The polyubiquitin gene ubiquitin C (UBC) is considered a stress protective gene and is
upregulated under various stressful conditions, which is probably a consequence of an …

[HTML][HTML] Protein-protein interaction network of celiac disease

MZ Azodi, H Peyvandi, M Rostami-Nejad… - … and Hepatology from …, 2016 - ncbi.nlm.nih.gov
Aim: The aim of this study is to investigate the Protein-Protein Interaction Network of Celiac
Disease. Background: Celiac disease (CD) is an autoimmune disease with susceptibility of …

Racial differences in genome-wide methylation profiling and gene expression in breast tissues from healthy women

MA Song, TM Brasky, C Marian, DY Weng, C Taslim… - Epigenetics, 2015 - Taylor & Francis
Breast cancer is more common in European Americans (EAs) than in African Americans
(AAs) but mortality from breast cancer is higher among AAs. While there are racial …

Effect of productive human papillomavirus 16 infection on global gene expression in cervical epithelium

SD Kang, S Chatterjee, S Alam, AC Salzberg… - Journal of …, 2018 - Am Soc Microbiol
Human papillomavirus (HPV) infection is the world's most common sexually transmitted
infection and is responsible for most cases of cervical cancer. Previous studies of global …