The major pathways of DNA double-strand break (DSB) repair are crucial for maintaining
genomic stability. However, if deployed in an inappropriate cellular context, these same …

The correct duplication and transmission of genetic material to daughter cells is the primary
objective of the cell division cycle. DNA replication and chromosome segregation present …

Genome editing has therapeutic potential for treating genetic diseases and cancer.
However, the currently most practicable approaches rely on the generation of DNA double …

DNA double-strand breaks (DSBs) are deleterious lesions that challenge genome integrity.
To mitigate this threat, human cells rely on the activity of multiple DNA repair machineries …

Nonhomologous end-joining (NHEJ) and homologous recombination (HR) are the primary
pathways for repairing DNA double-strand breaks (DSBs) during interphase, whereas …

The DNA damage response (DDR) generates transient repair compartments to concentrate
repair proteins and activate signaling factors. The physicochemical properties of these …

Genome editing has potential for the targeted correction of germline mutations. Here we
describe the correction of the heterozygous MYBPC3 mutation in human preimplantation …

Ubiquitylation is an essential posttranslational modification that controls cell division,
differentiation, and survival in all eukaryotes. By combining multiple E3 ligases (writers) …

The NLRP3 inflammasome responds to microbes and danger signals by processing and
activating proinflammatory cytokines, including interleukin 1β (IL-1β) and IL-18. We found …

The CRISPR/Cas9 system is a robust genome editing technology that works in human cells,
animals and plants based on the RNA-programmed DNA cleaving activity of the Cas9 …