Five small interfering RNA (siRNA)-based therapeutics have been approved by the Food
and Drug Administration (FDA), namely patisiran, givosiran, lumasiran, inclisiran, and …

Pseudomonas aeruginosa is an opportunistic pathogen that is responsible for infections in
people living with chronic respiratory conditions, such as cystic fibrosis (CF) and non-CF …

Serine proteases are members of a large family of hydrolytic enzymes in which a particular
serine residue in the active site performs an essential role as a nucleophile, which is …

Genetic variation in alpha-1 antitrypsin (AAT) causes AAT deficiency (AATD) through liver
aggregation-associated gain-of-toxic pathology and/or insufficient AAT activity in the lung …

This systematic review and meta-analysis appraised previous findings to uncover potential
faecal intestinal permeability and intestinal inflammatory markers in older adults. A …

Neutrophil extracellular traps (NETs) have emerged as a critical factor in malignant
hematologic disease pathogenesis. These structures, comprising DNA, histones, and …

Parasitoids introduce various virulence factors when parasitism occurs, and some taxa
generate teratocytes to manipulate the host immune system and metabolic homeostasis for …

Immune complex (IC)-driven formation of neutrophil extracellular traps (NETs) is a major
contributing factor to the pathogenesis of autoimmune diseases including systemic lupus …

The expression of the acute-phase reactants C-reactive protein (CRP), α1-antitrypsin (AAT),
and secretory leukocyte protease inhibitor (SLPI), is induced in response to inflammation by …

Cytoglobin (Cygb) is an evolutionary ancient heme protein with yet unclear physiological
function (s). Mammalian Cygb is ubiquitously expressed in all tissues and is proposed to be …