Background Preterm birth preceded by spontaneous preterm labour often occurs in the
clinical setting of sterile intra-amniotic inflammation (SIAI), a condition that currently lacks …

The LEPR gene encodes a leptin hormone receptor, and its mutations are associated with
morbid obesity, dysregulation of lipid metabolism, and fertility defects in humans …

Altered lipid metabolism in obesity causes pregnancy complications in humans and animals.
Leptin levels increase in pregnancy, as well as obesity. However, the effect of obesity on …

The purpose of this study was to determine the receptor subtype and the underlying
mechanisms involved in the relaxant effect to leptin in mid-and late-pregnant mouse uterus …

Obesity can have a significant impact on pregnancy outcomes by compromising the ability of
the uterus to relax, which increases the likelihood of conditions such as preterm labor. One …

Concentrations of the hormone leptin, which is produced by adipose tissue, increase with
increasing BMI, whereas leptin sensitivity often declines with higher BMI. Thus, altered leptin …

Endosal**iosis (ES) and endometriosis (EM) refer to the growth of tubal and endometrial
epithelium respectively, outside of their site of origin. We hypothesize that uterine secretome …

Goats were the first animals domesticated by humans. Farmers breed goats for their milk
and meat. Adequate feeding is inseparable from good breeding and productivity of goats …

The uterus as a smooth muscle has the basic contractile mechanism which is stimulated
either by depolarization or receptor agonists. Contractions of the uterus are regulated …

Gene editing is becoming increasingly widespread in work with farm animals. However, the
limited number of genes and traits used as editing targets suggests the need to develop …