Dynamics and functions of lipid droplets

JA Olzmann, P Carvalho - Nature reviews Molecular cell biology, 2019 - nature.com
Lipid droplets are storage organelles at the centre of lipid and energy homeostasis. They
have a unique architecture consisting of a hydrophobic core of neutral lipids, which is …

The perilipin family of lipid droplet proteins: Gatekeepers of intracellular lipolysis

C Sztalryd, DL Brasaemle - Biochimica et biophysica acta (bba)-molecular …, 2017 - Elsevier
Lipid droplets in chordates are decorated by two or more members of the perilipin family of
lipid droplet surface proteins. The perilipins sequester lipids by protecting lipid droplets from …

Lipid droplet biogenesis

TC Walther, J Chung… - Annual review of cell and …, 2017 - annualreviews.org
Lipid droplets (LDs) are ubiquitous organelles that store neutral lipids for energy or
membrane synthesis and act as hubs for metabolic processes. Cells generate LDs de novo …

Lipid droplets: a cellular organelle vital in cancer cells

Y **, Y Tan, J Wu, Z Ren - Cell death discovery, 2023 - nature.com
Lipid droplets (LDs) are cellular organelles comprising a core of neutral lipids (glycerides,
sterols) encased within a single phospholipid membrane, responsible for storing surplus …

Expanding roles for lipid droplets

MA Welte - Current biology, 2015 - cell.com
Lipid droplets are the intracellular sites for neutral lipid storage. They are critical for lipid
metabolism and energy homeostasis, and their dysfunction has been linked to many …

The biophysics and cell biology of lipid droplets

AR Thiam, RV Farese Jr, TC Walther - Nature reviews Molecular cell …, 2013 - nature.com
Lipid droplets are intracellular organelles that are found in most cells, where they have
fundamental roles in metabolism. They function prominently in storing oil-based reserves of …

Seipin is required for converting nascent to mature lipid droplets

H Wang, M Becuwe, BE Housden, C Chitraju… - elife, 2016 - elifesciences.org
How proteins control the biogenesis of cellular lipid droplets (LDs) is poorly understood.
Using Drosophila and human cells, we show here that seipin, an ER protein implicated in …

Targeting fat: mechanisms of protein localization to lipid droplets

N Kory, RV Farese, TC Walther - Trends in cell biology, 2016 - cell.com
How proteins specifically localize to the phospholipid monolayer surface of lipid droplets
(LDs) is being unraveled. We review here the major known pathways of protein targeting to …

The why, when and how of lipid droplet diversity

AR Thiam, M Beller - Journal of cell science, 2017 - journals.biologists.com
Lipid droplets are the universal cellular organelles for the transient or long-term storage of
lipids. The number, size and composition of lipid droplets vary greatly within cells in a …

Lipid droplet biogenesis

F Wilfling, JT Haas, TC Walther, RV Farese Jr - Current opinion in cell …, 2014 - Elsevier
Lipid droplets (LDs) are found in most cells, where they play central roles in energy and
membrane lipid metabolism. The de novo biogenesis of LDs is a fascinating, yet poorly …