Introduction Evidence-based recommendations are needed to guide the acute management
of the bleeding trauma patient. When these recommendations are implemented patient …

Rapid progress in trauma care occurs when the results of translational research are
promptly integrated into clinical practice. Experience with a high volume of severely injured …

Background Severe trauma continues to represent a global public health issue and mortality
and morbidity in trauma patients remains substantial. A number of initiatives have aimed to …

Background: Patients with severe traumatic injuries often present with coagulopathy and
require massive transfusion. The risk of death from hemorrhagic shock increases in this …

Background: Bleeding is the most frequent cause of preventable death after severe injury.
Coagulopathy associated with severe injury complicates the control of bleeding and is …

Objective: To determine the effect of blood component ratios in massive transfusion (MT), we
hypothesized that increased use of plasma and platelet to red blood cell (RBC) ratios would …

Damage control resuscitation has become a topic of increasing relevance and popularity
over the past several years. Hemorrhage accounts for 30% to 40% of trauma fatalities and is …

Background Acute blood loss in trauma requires quick identification and action to restore
circulating volume and save the patient. Massive transfusion protocols (MTPs) have become …

Cryoprecipitate, originally developed as a therapy for patients with antihaemophilic factor
deficiency, or haemophilia A, has been in use for almost 50 yr. However, cryoprecipitate is …

Background: The importance of early and aggressive management of trauma-related
coagulopathy remains poorly understood. We hypothesized that a trauma exsanguination …