The tumor microenvironment (TME) is composed of many different cellular and acellular
components that together drive tumor growth, invasion, metastasis, and response to …

Single-cell transcriptomics has broadened our understanding of cellular diversity and gene
expression dynamics in healthy and diseased tissues. Recently, spatial transcriptomics has …

The intestine is a complex organ that promotes digestion, extracts nutrients, participates in
immune surveillance, maintains critical symbiotic relationships with microbiota and affects …

Multiplexed immunofluorescence imaging allows the multidimensional molecular profiling of
cellular environments at subcellular resolution. However, identifying and characterizing …

Multiplexed imaging enables the simultaneous spatial profiling of dozens of biological
molecules in tissues at single-cell resolution. Extracting biologically relevant information …

Multiplexed imaging and spatial transcriptomics enable highly resolved spatial
characterization of cellular phenotypes, but still largely depend on laborious manual …

The rapidly develo** spatial omics generated datasets with diverse scales and modalities.
However, most existing methods focus on modeling dynamics of single cells while ignore …

Spatial omics technologies decipher functional components of complex organs at cellular
and subcellular resolutions. We introduce Spatial Graph Fourier Transform (SpaGFT) and …

Advances in multiplex histology allow surveying millions of cells, dozens of cell types, and
up to thousands of phenotypes within the spatial context of tissue sections. This leads to a …

Tissue imaging has become much more colourful in the past decade. Advances in both
experimental and analytical methods now make it possible to image protein markers in …