The pathogenesis of Parkinson's disease
Parkinson's disease is a progressive neurodegenerative condition associated with the
deposition of aggregated α-synuclein. Insights into the pathogenesis of Parkinson's disease …
deposition of aggregated α-synuclein. Insights into the pathogenesis of Parkinson's disease …
Autophagy in Parkinson's disease
L Nechushtai, D Frenkel, R Pinkas-Kramarski - Biomolecules, 2023 - mdpi.com
Parkinson's disease (PD) is a devastating disease associated with accumulation of α-
synuclein (α-Syn) within dopaminergic neurons, leading to neuronal death. PD is …
synuclein (α-Syn) within dopaminergic neurons, leading to neuronal death. PD is …
[HTML][HTML] Clinical and neurochemical correlates of the APOE genotype in early-stage Parkinson's disease
H Zenuni, R Bovenzi, J Bissacco, P Grillo… - Neurobiology of …, 2023 - Elsevier
Emerging evidence indicates that apolipoprotein E (APOE) genotype may influence
Parkinson's disease (PD) course, although clinical and neurochemical correlates have not …
Parkinson's disease (PD) course, although clinical and neurochemical correlates have not …
[HTML][HTML] Pathobiology of cognitive impairment in Parkinson disease: challenges and outlooks
KA Jellinger - International Journal of Molecular Sciences, 2023 - mdpi.com
Cognitive impairment (CI) is a characteristic non-motor feature of Parkinson disease (PD)
that poses a severe burden on the patients and caregivers, yet relatively little is known about …
that poses a severe burden on the patients and caregivers, yet relatively little is known about …
LRP10 and α-synuclein transmission in Lewy body diseases
A Carreras Mascaro, MM Grochowska… - Cellular and Molecular …, 2024 - Springer
Autosomal dominant variants in LRP10 have been identified in patients with Lewy body
diseases (LBDs), including Parkinson's disease (PD), Parkinson's disease-dementia (PDD) …
diseases (LBDs), including Parkinson's disease (PD), Parkinson's disease-dementia (PDD) …
LDL Receptor-Related Protein 1B Polymorphisms Associated with Increased Risk of Lymph Node Metastasis in Oral Cancer Group with Diabetes Mellitus
LC Chen, YS Lo, HY Ho, CC Lin, YC Chuang… - International Journal of …, 2024 - mdpi.com
Oral cancer ranks fourth among malignancies among Taiwanese men and is the eighth most
common cancer among men worldwide in terms of general diagnosis. The purpose of the …
common cancer among men worldwide in terms of general diagnosis. The purpose of the …
Lower activity of cholesteryl ester transfer protein (CETP) and the risk of dementia: a Mendelian randomization analysis
AF Schmidt, MH Davidson, M Ditmarsch… - Alzheimer's research & …, 2024 - Springer
Background Elevated concentrations of low-density lipoprotein cholesterol (LDL-C) are
linked to dementia risk, and conversely, increased plasma concentrations of high-density …
linked to dementia risk, and conversely, increased plasma concentrations of high-density …
Mutational landscape of risk variants in comorbid depression and obesity: a next-generation sequencing approach
Major depression (MD) and obesity are complex genetic disorders that are frequently
comorbid. However, the study of both diseases concurrently remains poorly addressed and …
comorbid. However, the study of both diseases concurrently remains poorly addressed and …
Unraveling the complex role of MAPT-containing H1 and H2 haplotypes in neurodegenerative diseases
A~ 1 Mb inversion polymorphism exists within the 17q21. 31 locus of the human genome as
direct (H1) and inverted (H2) haplotype clades. This inversion region demonstrates high …
direct (H1) and inverted (H2) haplotype clades. This inversion region demonstrates high …
Genome-wide determinants of mortality and motor progression in Parkinson's disease
There are 90 independent genome-wide significant genetic risk variants for Parkinson's
disease (PD) but currently only five nominated loci for PD progression. The biology of PD …
disease (PD) but currently only five nominated loci for PD progression. The biology of PD …