The mammary gland is a highly dynamic organ that undergoes profound changes within its
epithelium during puberty and the reproductive cycle. These changes are fueled by …

The mammary gland is a compound, branched tubuloalveolar structure and a major
characteristic of mammals. The mammary gland has evolved from epidermal apocrine …

Adipose tissue is a complex endocrine organ, with a role in obesity and cancer. Adipose
tissue is generally linked to excessive body fat, and it is well known that the female breast is …

The mammary gland is one of the most regenerative organs in the body, with the majority of
development occurring postnatally and in the adult mammal. Formation of the ductal tree is …

WNT signaling is crucial for tissue morphogenesis during development in all multicellular
animals. After birth, WNT/CTNNB1 responsive stem cells are responsible for tissue …

Animal models of cancer have been instrumental in advancing our understanding of the
biology of tumor initiation and progression, in studying gene function and in performing …

The mammary gland is a unique tissue and the defining feature of the class Mammalia. It is a
late-evolving epidermal appendage that has the primary function of providing nutrition for …

Maintenance of undifferentiated, long-lived, and often quiescent stem cells in the basal
compartment is important for homeostasis and regeneration of multiple epithelial tissues, but …

The Wnt pathway has emerged as a key signaling cascade participating in mammary
organogenesis and breast oncogenesis. In this review, we will summarize the current …

The Wnt cascade is a primordial developmental signaling pathway that plays a myriad of
essential functions throughout development and adult homeostasis in virtually all animal …