Abnormal choline metabolism is emerging as a metabolic hallmark that is associated with
oncogenesis and tumour progression. Following transformation, the modulation of enzymes …

Following the impetus of early clinical and experimental investigations, in vivo and in vitro
MRS studies of tumours pointed in the eighties to the possible significance of signals arising …

MATERIALS AND METhODS Patients With our ethics committee's approval and the patients'
informed consent, 10 patients who were admitted to the urology department of our hospital …

The literature describing 31P, 1H, 13C, 23Na and 19F MRS in vivo in human cancers is
reviewed. Cancers have typical metabolic characteristics in 31P and 1H MRS including high …

The endoplasmic reticulum (ER) is an interconnected network of tubular and planar
membranes that supports the synthesis and export of proteins, carbohydrates and lipids …

The current status of the biochemistry of phospholipid biosynthesis is presented. The review
focuses on the identification and characterization of molecular tools such as purified …

Ca2+-mobilizing agonists, including hormones, neurotrans-mitters and growth factors, cause
profound changes in cellular lipid metabolism. These changes are initiated by receptor …

Choline kinase (CK) catalyzes the first phosphorylation reaction in the CDP-choline pathway
for the biosynthesis of phosphatidylcholine (PC), yielding phosphocholine (P-Cho) from …

Addition of choline, ethanolamine, or hemicholinium-3 (a choline kinase inhibitor) to the
perfusate of human breast cancer cells monitored by 31P NMR spectroscopy resulted in …

Summary p21ras is a small GTPase that functions as a molecular switch in signal
transduction from activated receptor tyrosine kinases to cellular targets. Recently, progress …