Deep sequencing of B cell receptor repertoires from COVID-19 patients reveals strong convergent immune signatures

JD Galson, S Schaetzle, RJM Bashford-Rogers… - Frontiers in …, 2020 - frontiersin.org
Deep sequencing of B cell receptor (BCR) heavy chains from a cohort of 31 COVID-19
patients from the UK reveals a stereotypical naive immune response to SARS-CoV-2 which …

Maturation of the human immunoglobulin heavy chain repertoire with age

M Ghraichy, JD Galson, A Kovaltsuk… - Frontiers in …, 2020 - frontiersin.org
B cells play a central role in adaptive immune processes, mainly through the production of
antibodies. The maturation of the B cell system with age is poorly studied. We extensively …

Distinction between peanut allergy and tolerance by characterization of B cell receptor repertoires

AM Ehlers, CF den Hartog Jager, AC Knulst, HG Otten - Allergy, 2021 - Wiley Online Library
Abstract Background Specific IgE against a peanut 2S albumin (Ara h 2 or 6) is the best
predictor of clinically relevant peanut sensitization. However, sIgE levels of peanut allergic …

A cell-based in vitro assay for testing of immunological integrity of Tetanus toxoid vaccine antigen

O Ticha, D Klemm, L Moos, I Bekeredjian-Ding - npj Vaccines, 2021 - nature.com
Vaccines containing inactivated toxins confer protection by eliciting a neutralizing antibody
response against bacterial toxins such as tetanus and diphtheria. At present, release of …