The extracellular matrix (ECM) is the noncellular component present within all tissues and
organs, and provides not only essential physical scaffolding for the cellular constituents but …

A cell undergoes many genetic and epigenetic changes as it transitions to malignancy.
Malignant transformation is also accompanied by a progressive loss of tissue homeostasis …

Tumors are characterized by extracellular matrix (ECM) remodeling and stiffening. The
importance of ECM remodeling to cancer is appreciated; the relevance of stiffening is less …

Matrix stiffness potently regulates cellular behaviour in various biological contexts. In breast
tumours, the presence of dense clusters of collagen fibrils indicates increased matrix …

Cancer recurrence after initial diagnosis and treatment is a major cause of breast cancer
(BC) mortality, which results from the metastatic outbreak of dormant tumour cells …

In situ, cells are highly sensitive to geometrical and mechanical constraints from their
microenvironment. These parameters are, however, uncontrolled under classic culture …

Mechanical cues from the extracellular matrix (ECM) regulate various cellular processes via
distinct mechanotransduction pathways. In breast cancer, increased ECM stiffness promotes …

Increased overall survival for patients with glioma brain tumours is associated with mutations
in the metabolic regulator isocitrate dehydrogenase 1 (IDH1). Gliomas develop within a …

Tissue mechanics regulate development and homeostasis and are consistently modified in
tumor progression. Nevertheless, the fundamental molecular mechanisms through which …

Women with dense breasts have an increased lifetime risk of malignancy that has been
attributed to a higher epithelial density. Quantitative proteomics, collagen analysis, and …