Genome-wide transcriptome analyses are routinely used to monitor tissue-, disease-and cell
type–specific gene expression, but it has been technically challenging to generate …

Alternative splicing of pre-messenger RNA is a key feature of transcriptome expansion in
eukaryotic cells, yet its regulation is poorly understood. Spliceosome assembly occurs co …

One of the challenges of bioinformatics is to develop effective ways to analyze global gene
expression data. A rigorous approach to gene expression analysis must involve an up-front …

DNA microarrays are currently used to study the transcriptional response of many organisms
to genetic and environmental perturbations. Although there is much room for improvement of …

Praise for the Second Edition:" The authors present an intuitive and easy-to-read book.…
accompanied by many examples, proposed exercises, good references, and …

Introduction Migraine with aura (MwA) is a neurological condition manifested in moderate to
severe headaches associated with transient visual and somatosensory symptoms, as well …

This paper addresses the problem of reconstructing a low-rank signal matrix observed with
additive Gaussian noise. We first establish that, under mild assumptions, one can restrict …

Large-scale affinity purification and mass spectrometry studies have played important roles
in the assembly and analysis of comprehensive protein interaction networks for lower …

Background Microarray experiments are becoming a powerful tool for clinical diagnosis, as
they have the potential to discover gene expression patterns that are characteristic for a …

Abstract Background The 27k Illumina Infinium Methylation Beadchip is a popular high-
throughput technology that allows the methylation state of over 27,000 CpGs to be assayed …