The delayed and prolonged postmitotic maturation of human neurons, compared with
neurons from other species, may contribute to human-specific cognitive abilities and …

Since the beautiful images of Santiago Ramón y Cajal provided a first glimpse into the
immense diversity and complexity of cell types found in the cerebral cortex, neuroscience …

INTRODUCTION The brain of mammals consists of an enormously dense network of
neuronal wires: the axons and dendrites of nerve cells. Their packing density is so high that …

Astrocytes regulate the formation and function of neuronal synapses via multiple signals;
however, what controls regional and temporal expression of these signals during …

Connections between the thalamus and cortex develop rapidly before birth, and aberrant
cerebral maturation during this period may underlie a number of neurodevelopmental …

GABAergic activity is thought to influence develo** neocortical sensory circuits. Yet the
late postnatal maturation of local layer (L) 4 circuits suggests alternate sources of GABAergic …

Abstract Development passes through sensitive periods, during which plasticity allows for
genetic and environmental factors to exert indelible influence on the maturation of the …

Conscious perception in mammals depends on precise circuit connectivity between cerebral
cortex and thalamus; the evolution and development of these structures are closely linked …

Pharmacologic blockade of monoamine oxidase A (MAOA) or serotonin transporter (5-HTT)
has antidepressant and anxiolytic efficacy in adulthood. Yet, genetically conferred MAOA or …

It is often thought that the construction of cortical circuits occurs as the result of an elegantly
designed process that unfolds sequentially as an animal develops until adult functional …