Renin-angiotensin system (RAS) inhibitors (RASi)—widely prescribed for the treatment of
cardiovascular diseases—have considerable potential in oncology. The RAS plays a crucial …

At high concentrations, free radicals and radical-derived, nonradical reactive species are
hazardous for living organisms and damage all major cellular constituents. At moderate …

During infections or acute conditions high-density lipoproteins cholesterol (HDL-C) levels
decrease very rapidly and HDL particles undergo profound changes in their composition …

The immune system of an organism is an essential component of the defense mechanism
aimed at combating pathogenic stress. Age-associated immune dysfunction, also dubbed …

At the present time, regulatory T cells (Tregs) are an integral part of immunology but the
route from discovery of “suppressive” lymphocytes in the 1980s to the current established …

Receptor-stimulated generation of reactive oxygen species (ROS) has been shown to
regulate signal transduction, and previous studies have suggested that T cell receptor (TCR) …

Reactive oxygen species (ROS) are produced mainly during oxidative phosphorylation and
by activated phagocytic cells during oxidative burst. The excessive production of ROS can …

Reactive oxygen species (ROS) are thought to have effects on T-cell function and
proliferation. Low concentrations of ROS in T cells are a prerequisite for cell survival, and …

Reactive oxygen species (ROS) play important roles in cell signaling and tissue
homeostasis, in which the level of ROS is critical through the equilibrium between ROS …

The phagocyte NAPDH–oxidase complex consists of several phagocyte oxidase (phox)
proteins, generating reactive oxygen species (ROS) upon activation. ROS are involved in …