Serial femtosecond crystallography
With the advent of X-ray free-electron lasers (XFELs), new, high-throughput serial
crystallography techniques for macromolecular structure determination have emerged …
crystallography techniques for macromolecular structure determination have emerged …
Advances and challenges in time-resolved macromolecular crystallography
BACKGROUND Conformational changes are essential for the correct functioning of
biological macromolecules. Time-resolved x-ray crystallography extends an extremely …
biological macromolecules. Time-resolved x-ray crystallography extends an extremely …
Retinal isomerization in bacteriorhodopsin captured by a femtosecond x-ray laser
INTRODUCTION Retinal is a light-sensitive protein ligand that is used by all domains of life
to process the information and energy content of light. Retinal-binding proteins are integral …
to process the information and energy content of light. Retinal-binding proteins are integral …
[HTML][HTML] SwissFEL: the Swiss X-ray free electron laser
The SwissFEL X-ray Free Electron Laser (XFEL) facility started construction at the Paul
Scherrer Institute (Villigen, Switzerland) in 2013 and will be ready to accept its first users in …
Scherrer Institute (Villigen, Switzerland) in 2013 and will be ready to accept its first users in …
Linac coherent light source: The first five years
A new scientific frontier opened in 2009 with the start of operations of the world's first x-ray
free-electron laser (FEL), the Linac Coherent Light Source (LCLS), at SLAC National …
free-electron laser (FEL), the Linac Coherent Light Source (LCLS), at SLAC National …
Carotenoids and photosynthesis
Carotenoids are ubiquitous and essential pigments in photosynthesis. They absorb in the
blue-green region of the solar spectrum and transfer the absorbed energy to (bacterio-) …
blue-green region of the solar spectrum and transfer the absorbed energy to (bacterio-) …
Femtosecond structural dynamics drives the trans/cis isomerization in photoactive yellow protein
A variety of organisms have evolved mechanisms to detect and respond to light, in which the
response is mediated by protein structural changes after photon absorption. The initial step …
response is mediated by protein structural changes after photon absorption. The initial step …
Deciphering photoinduced catalytic reaction mechanisms in natural and artificial photosynthetic systems on multiple temporal and spatial scales using X-ray probes
Utilization of renewable energies for catalytically generating value-added chemicals is
highly desirable in this era of rising energy demands and climate change impacts. Artificial …
highly desirable in this era of rising energy demands and climate change impacts. Artificial …
Synthetic biology for the directed evolution of protein biocatalysts: navigating sequence space intelligently
The amino acid sequence of a protein affects both its structure and its function. Thus, the
ability to modify the sequence, and hence the structure and activity, of individual proteins in …
ability to modify the sequence, and hence the structure and activity, of individual proteins in …
Time-resolved serial crystallography captures high-resolution intermediates of photoactive yellow protein
Serial femtosecond crystallography using ultrashort pulses from x-ray free electron lasers
(XFELs) enables studies of the light-triggered dynamics of biomolecules. We used …
(XFELs) enables studies of the light-triggered dynamics of biomolecules. We used …