Despite the fact that great efforts have been made in the prevention and therapy of HIV-1
infection, HIV-1/AIDS remains a major threat to global human health. Highly active …

Although tremendous efforts have been made to prevent and treat HIV-1 infection, HIV-
1/AIDS remains a major threat to global human health. The combination antiretroviral …

CRISPR/Cas9 is an adaptive immune system where bacteria and archaea have evolved to
resist the invading viruses and plasmid DNA by creating site-specific double-strand breaks …

The clustered regularly interspaced short palindromic repeats (CRISPR)-associated Cas9
system has been used to excise the HIV-1 proviral genome from latently infected cells …

Defining the variables that impact the specificity of CRISPR/Cas9 has been a major research
focus. Whereas sequence complementarity between guide RNA and target DNA …

Clustered regularly interspaced short palindromic repeats (CRISPR) CRISPR-associated
protein 9 (Cas9), including specific guide RNAs (gRNAs), can excise integrated human …

Although combination antiretroviral therapy (ART) has reduced mortality and improved
lifespan for people living with HIV, it does not provide a cure. Patients must be on ART for …

The CRISPR/Cas9 system has been proposed as a cure strategy for HIV. However, few
published guide RNAs (gRNAs) are predicted to cleave the majority of HIV-1 viral …

In the last 2 decades, a wide variety of studies have been conducted on epigenetics and its
role in various cancers. A major mechanism of epigenetic regulation is DNA methylation …

Abstract Background CRISPR/CAS9 (epi) genome editing revolutionized the field of gene
and cell therapy. Our previous study demonstrated that a rapid and robust reactivation of the …