A review on recent advances in nitrogen-containing molecules and their biological applications
The analogs of nitrogen-based heterocycles occupy an exclusive position as a valuable
source of therapeutic agents in medicinal chemistry. More than 75% of drugs approved by …
source of therapeutic agents in medicinal chemistry. More than 75% of drugs approved by …
Inhibitory potential of nitrogen, oxygen and sulfur containing heterocyclic scaffolds against acetylcholinesterase and butyrylcholinesterase
Heterocycles are the key structures in organic chemistry owing to their immense applications
in the biological, chemical, and pharmaceutical fields. Heterocyclic compounds perform …
in the biological, chemical, and pharmaceutical fields. Heterocyclic compounds perform …
Recent Advances in the Green Synthesis of Active N-Heterocycles and Their Biological Activities
N-heterocyclic scaffolds represent a privileged architecture in the process of drug design
and development. It has widespread occurrence in synthetic and natural products, either …
and development. It has widespread occurrence in synthetic and natural products, either …
Development of novel bosentan analogues as endothelin receptor antagonists for pulmonary arterial hypertension
Since decades, bosentan has been in use for the treatment of pulmonary arterial
hypertension (PAH). However, chronic exposure to bosentan leads to the development of …
hypertension (PAH). However, chronic exposure to bosentan leads to the development of …
[HTML][HTML] The application of hydrazones and hydrazide-hydrazones in the synthesis of bioactive azetidin-2-one derivatives: A mini review
Ł Popiołek - Biomedicine & Pharmacotherapy, 2023 - Elsevier
The hydrazones and hydrazide-hydrazones beside possessing crucial bioactivity can serve
as useful intermediates in the synthesis of heterocyclic systems like 1, 3-benzothiazin-4-one …
as useful intermediates in the synthesis of heterocyclic systems like 1, 3-benzothiazin-4-one …
β-Lactams as promising anticancer agents: Molecular hybrids, structure activity relationships and potential targets
DJ Fu, YF Zhang, AQ Chang, J Li - European Journal of Medicinal …, 2020 - Elsevier
Abstract β-Lactam, commonly referred as azetidin-2-one, is a multifunctional building block
for synthesizing β-amino ketones, γ-amino alcohols, and other compounds. Besides its well …
for synthesizing β-amino ketones, γ-amino alcohols, and other compounds. Besides its well …
Stereoselective Kinugasa/Aldol Cyclization: Synthesis of Enantioenriched Spirocyclic β-Lactams
A Torelli, ES Choi, A Dupeux, MN Perner… - Organic …, 2023 - ACS Publications
We report an enantioselective copper-catalyzed Kinugasa/aldol domino reaction. This
strategy enables access to a range of spirocyclic β-lactam pyrrolidinones in a …
strategy enables access to a range of spirocyclic β-lactam pyrrolidinones in a …
N-tert-Butanesulfinyl imines in the asymmetric synthesis of nitrogen-containing heterocycles
JA Mendes, PRR Costa, M Yus… - Beilstein Journal of …, 2021 - beilstein-journals.org
The synthesis of nitrogen-containing heterocycles, including natural alkaloids and other
compounds presenting different types of biological activities have proved to be successful …
compounds presenting different types of biological activities have proved to be successful …
Facile synthesis of azetidine nitrones and diastereoselective conversion into densely substituted azetidines
An electrocyclization route to azetidine nitrones from N‐alkenylnitrones was discovered that
provides facile access to these unsaturated strained heterocycles. Reactivity studies showed …
provides facile access to these unsaturated strained heterocycles. Reactivity studies showed …
Current updates on green synthesis and biological properties of 4-quinolone derivatives
The chemistry of quinolones, representing one of the major classes of nitrogen-containing
heterocyclics, has received more attention and considered one of the promising …
heterocyclics, has received more attention and considered one of the promising …