Glioblastoma multiforme is the most aggressive malignant tumor of the central nervous
system. Due to the absence of effective pharmacological and surgical treatments, the …

A G-quadruplex (G4) is a well-known nucleic acid secondary structure comprising guanine-
rich sequences, and has profound implications for various pharmacological and biological …

The molecular foundations of Hürthle cell carcinoma (HCC) are poorly understood. Here we
describe a comprehensive genomic characterization of 56 primary HCC tumors that span …

Eukaryotic cells undergo continuous telomere shortening as a consequence of multiple
rounds of replications. During tumorigenesis, cells have to acquire telomere DNA …

Introduction: ATRX is a chromatin remodeling protein whose main function is the deposition
of the histone variant H3. 3. ATRX mutations are widely distributed in glioma, and correlate …

Tumour cells can adopt telomere maintenance mechanisms (TMMs) to avoid telomere
shortening, an inevitable process due to successive cell divisions. In most tumour cells …

Uterine leiomyosarcomas (uLMS) are aggressive tumors arising from the smooth muscle
layer of the uterus. We analyzed 83 uLMS sample genetics, including 56 from Yale and 27 …

Cancers require telomere maintenance mechanisms for unlimited replicative potential. They
achieve this through TERT activation or alternative telomere lengthening associated with …

Diffuse IDH-mutant astrocytic tumors are rarely diagnosed in the cerebellum or brainstem. In
this multi-institutional study, we characterized a series of primary infratentorial IDH-mutant …

Only one class of targeted agents (anti-GD2 antibodies) has been incorporated into front-
line therapy for neuroblastoma since the 1980s. The Neuroblastoma New Drug …