The neuropathobiology of multiple sclerosis

MS Woo, JB Engler, MA Friese - Nature Reviews Neuroscience, 2024 - nature.com
Chronic low-grade inflammation and neuronal deregulation are two components of a
smoldering disease activity that drives the progression of disability in people with multiple …

Multiple sclerosis: inflammatory and neuroglial aspects

G Papiri, G D'Andreamatteo, G Cacchiò, S Alia… - Current Issues in …, 2023 - mdpi.com
Multiple sclerosis (MS) represents the most common acquired demyelinating disorder of the
central nervous system (CNS). Its pathogenesis, in parallel with the well-established role of …

Revisiting the pathoetiology of multiple sclerosis: has the tail been wagging the mouse?

MK Sen, MSM Almuslehi, PJ Shortland… - Frontiers in …, 2020 - frontiersin.org
Multiple Sclerosis (MS) is traditionally considered an autoimmune-mediated demyelinating
disease, the pathoetiology of which is unknown. However, the key question remains whether …

Lipocalin 2 attenuates oligodendrocyte loss and immune cell infiltration in mouse models for multiple sclerosis

N Gasterich, A Bohn, A Sesterhenn, F Nebelo, L Fein… - Glia, 2022 - Wiley Online Library
Multiple sclerosis (MS) is a central nervous system disease characterized by both
degenerative and inflammatory processes. Various mediators are involved in the interplay of …

Wuzi Yanzong Pill relieves CPZ-induced demyelination by improving the microenvironment in the brain

YR Li, MY Sun, W Hang, Q **ao, HJ Fan, L Jia, XM **… - Heliyon, 2022 - cell.com
Abstract Ethnopharmacology relevance Wuzi Yanzong Pill (WYP), a well-known prescription
for invigorating the kidney and essence, which is widely used to treat infertility such as …

Lipocalin-2 as a mediator of neuroimmune communication

R Afridi, JH Kim, A Bhusal, WH Lee… - Journal of Leukocyte …, 2024 - academic.oup.com
Abstract Lipocalin-2, a neutrophil gelatinase-associated lipocalin, is a 25-kDa secreted
protein implicated in a broad range of inflammatory diseases affecting the brain and …

[HTML][HTML] Abnormal oxidative metabolism in the cuprizone mouse model of demyelination: An in vivo NIRS-MRI study

M Hashem, Q Shafqat, Y Wu, JM Rho, JF Dunn - Neuroimage, 2022 - Elsevier
Disruptions in oxidative metabolism may occur in multiple sclerosis and other demyelinating
neurological diseases. The impact of demyelination on metabolic rate is also not …

Construction and validation of a novel cuproptosis-mitochondrion prognostic model related with tumor immunity in osteosarcoma

J Feng, J Wang, Y Xu, F Lu, J Zhang, X Han, C Zhang… - Plos one, 2023 - journals.plos.org
Background The purpose of this study was to develop a new prognostic model for
osteosarcoma based on cuproptosis-mitochondrion genes. Materials and methods The data …

Copper homeostasis and neurodegenerative diseases

Y Wang, D Li, K Xu, G Wang… - Neural Regeneration …, 2025 - journals.lww.com
Copper, one of the most prolific transition metals in the body, is required for normal brain
physiological activity and allows various functions to work normally through its range of …

[HTML][HTML] Titration of cuprizone induces reliable demyelination

N Wigger, J Krüger, E Vankriekelsvenne, M Kipp - Brain Research, 2025 - Elsevier
Multiple Sclerosis (MS) is a chronic inflammatory disease of the central nervous system.
Cuprizone-induced demyelination, wherein mice are fed a diet containing the copper …