The natriuretic peptide (NP) system is an important endocrine, autocrine and paracrine
system, consisting of a family of peptides which provide cardiac, renal and vascular effects …

Opinion statement This review provides mechanistic insight in the pleiotropic effects of
sodium-glucose transporter-2 (SGLT-2) inhibitors with particular interest to the …

Objectives: The purpose of this study was to assess the prognostic value of the estimation of
plasma volume or of its variation beyond clinical examination in a post-hoc analysis of …

Clinically unrecognized intravascular volume overload may contribute to worsening
symptoms and disease progression in patients with chronic heart failure (CHF). The present …

Background—We evaluated the effect of the selective mineralocorticoid receptor antagonist
eplerenone on renal function and the interaction between changes in renal function and …

Aims Plasma volume (PV) expansion hallmarks worsening chronic heart failure (CHF) but
no non‐invasive means of quantifying volume status exists. Because weight and …

Aims Uncertainties remain on the biological and prognostic significance and therapeutic
implications of loss in body weight (W‐LOSS) in chronic heart failure (HF) patients. We …

Objective Liver dysfunction due to heart failure (HF) is known as congestive hepatopathy. It
has recently been reported that liver stiffness assessed by transient elastography reflects …

Until recently, most studies of heart failure (HF) focused on body fluid dynamics through
control of the sodium and water balance in the body. Chloride has remained largely ignored …

Measurement of impedance is becoming increasingly available in the clinical setting as a
tool for assessing hemodynamics and volume status in patients with heart failure. The 2 …