There are two main mechanisms by which cells become multidrug resistant (MDR): by
increasing drug efflux pumps on the cell membrane and by increasing anti-apoptotic …

Dysregulation of histone deacetylases (HDACs) is closely related to tumor development and
progression. As promising anticancer targets, HDACs have gained a great deal of research …

Hyaluronic acid-ceramide (HA-CE)-based self-assembled nanoparticles were developed for
intravenous docetaxel (DCT) delivery. In this study, physicochemical properties, cellular …

Overexpression of drug efflux transport ABCB1 is correlated with multidrug resistance (MDR)
among cancer cells. Upregulation of ABCB1 accounts for the recurrence of resistance to …

Drug resistance is a primary hindrance towards curative cancer chemotherapy.
Nanotechnology holds great promise in establishing efficacious and innovative strategies to …

The carrier role of exosomes from human umbilical cord mesenchymal stem cells
(hUCMSCs) containing microRNAs (miRNAs) has been implicated in gene and drug …

Intraperitoneal (IP) chemotherapy is an effective way of treating local and regional
malignancies confined in the peritoneal cavity such as ovarian cancer. However, a …

Introductions Ovarian cancer is a stubborn malignancy of gynecological system with a high
mortality rate. Docetaxel (DTX), the second-generation of anti-tumor drug Taxane, has …

Cepharanthine, a natural bisbenzylisoquinoline (BBIQ) alkaloid isolated from the plant
Stephania Cephalantha Hayata, is the only bisbenzylisoquinoline alkaloid approved for …

Background Docetaxel (DTX) has been used to treat numerous types of cancers. It's poor
solubility, serious side effects, and multi-drug resistance (MDR) limits its use in cancer …