Loss of normal kidney function affects more than 10% of the population and contributes to
morbidity and mortality. Kidney diseases are currently treated with immunosuppressive …

Amplification of oxidative stress is present since the early stages of chronic kidney disease
(CKD), holding a key position in the pathogenesis of renal failure. Induction of renal pro …

Metabolic and haemodynamic perturbations and their interaction drive the development of
diabetic kidney disease (DKD) and its progression towards end stage renal disease (ESRD) …

Diabetic kidney disease (DKD) is a long-term and serious complication of diabetes that
affects millions of people worldwide. It is characterized by proteinuria, glomerular damage …

Mitochondria are perhaps the most sophisticated and dynamic responsive sensing systems
in eukaryotic cells. The role of mitochondria goes beyond their capacity to create molecular …

The molecular signaling mechanisms between glomerular cell types during
initiation/progression of diabetic kidney disease (DKD) remain poorly understood. We …

Sodium-glucose cotransporter 2 (SGLT2) inhibitors have pleiotropic properties beyond
blood glucose–lowering effects and modify important nonglycemic pathways, leading to end …

Diabetic kidney disease, commonly termed diabetic nephropathy (DN), is the most common
cause of end-stage kidney disease (ESKD) worldwide. The characteristic histopathology of …

Diabetic kidney disease (DKD) remains a leading cause of new-onset end-stage renal
disease (ESRD), and yet, at present, the treatment is still very limited. A better understanding …

Focal segmental glomerular sclerosis (FSGS) is a primary kidney disease that is commonly
associated with proteinuria and progressive loss of glomerular function, leading to …