Tissue fibrosis induced by radiotherapy: current understanding of the molecular mechanisms, diagnosis and therapeutic advances

Z Yu, C Xu, B Song, S Zhang, C Chen, C Li… - Journal of translational …, 2023 - Springer
Cancer remains the leading cause of death around the world. In cancer treatment, over 50%
of cancer patients receive radiotherapy alone or in multimodal combinations with other …

Radiation-induced lung injury (RILI)

L Giuranno, J Ient, D De Ruysscher, MA Vooijs - Frontiers in oncology, 2019 - frontiersin.org
Radiation pneumonitis (RP) and radiation fibrosis (RF) are two dose-limiting toxicities of
radiotherapy (RT), especially for lung, and esophageal cancer. It occurs in 5–20% of …

Targeting oxidative stress as a therapeutic approach for idiopathic pulmonary fibrosis

C Estornut, J Milara, MA Bayarri, N Belhadj… - Frontiers in …, 2022 - frontiersin.org
Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial lung disease characterized by an
abnormal reepithelialisation, an excessive tissue remodelling and a progressive fibrosis …

Strategies to improve radiotherapy with targeted drugs

AC Begg, FA Stewart, C Vens - Nature Reviews Cancer, 2011 - nature.com
Radiotherapy is used to treat approximately 50% of all cancer patients, with varying success.
The dose of ionizing radiation that can be given to the tumour is determined by the sensitivity …

ICRP publication 118: ICRP statement on tissue reactions and early and late effects of radiation in normal tissues and organs–threshold doses for tissue reactions in a …

FA Stewart, AV Akleyev, M Hauer-Jensen, JH Hendry… - Annals of the ICRP, 2012 - Elsevier
This report provides a review of early and late effects of radiation in normal tissues and
organs with respect to radiation protection. It was instigated following a recommendation in …

Peroxynitrite: biochemistry, pathophysiology and development of therapeutics

C Szabó, H Ischiropoulos, R Radi - Nature reviews Drug discovery, 2007 - nature.com
Peroxynitrite—the product of the diffusion-controlled reaction of nitric oxide with superoxide
radical—is a short-lived oxidant species that is a potent inducer of cell death. Conditions in …

Inhibition of Bcl-2/xl with ABT-263 selectively kills senescent type II pneumocytes and reverses persistent pulmonary fibrosis induced by ionizing radiation in mice

J Pan, D Li, Y Xu, J Zhang, Y Wang, M Chen… - International Journal of …, 2017 - Elsevier
Purpose Ionizing radiation (IR)–induced pulmonary fibrosis (PF) is an irreversible and
severe late effect of thoracic radiation therapy. The goal of this study was to determine …

Metabolic oxidation/reduction reactions and cellular responses to ionizing radiation: a unifying concept in stress response biology

DR Spitz, EI Azzam, J Jian Li, D Gius - Cancer and Metastasis Reviews, 2004 - Springer
Exposure of eukaryotic cells to ionizing radiation (IR) results in the immediate formation of
free radicals that last a matter of milliseconds. It has been assumed that the subsequent …

[BUKU][B] Handbook Of Porphyrin Science: With Applications To Chemistry, Physics, Materials Science, Engineering, Biology And Medicine (Volumes 6-10)

KM Kadish, R Guilard, KM Smith - 2010 - books.google.com
This is the second set of Handbook of Porphyrin Science. Porphyrins, phthalocyanines and
their numerous analogues and derivatives are materials of tremendous importance in …

Superoxide dismutase mimics: chemistry, pharmacology, and therapeutic potential

I Batinić-Haberle, JS Rebouças… - Antioxidants & redox …, 2010 - liebertpub.com
Oxidative stress has become widely viewed as an underlying condition in a number of
diseases, such as ischemia–reperfusion disorders, central nervous system disorders …