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Prefrontal cortex and depression
The prefrontal cortex (PFC) has emerged as one of the regions most consistently impaired in
major depressive disorder (MDD). Although functional and structural PFC abnormalities …
major depressive disorder (MDD). Although functional and structural PFC abnormalities …
Toward a better understanding of the mechanisms and pathophysiology of anhedonia: are we ready for translation?
Anhedonia—the loss of pleasure or lack of reactivity to pleasurable stimuli—remains a
formidable treatment challenge across neuropsychiatric disorders. In major depressive …
formidable treatment challenge across neuropsychiatric disorders. In major depressive …
The future of rodent models in depression research
Currently, over 300 million people worldwide have depression, and the socioeconomic
burden of this debilitating disorder is anticipated to increase markedly over the coming …
burden of this debilitating disorder is anticipated to increase markedly over the coming …
Assessing anhedonia in depression: Potentials and pitfalls
The resurgence of interest in anhedonia within major depression has been fuelled by
clinical trials demonstrating its utility in predicting antidepressant response as well as recent …
clinical trials demonstrating its utility in predicting antidepressant response as well as recent …
Rodent models of post-traumatic stress disorder: behavioral assessment
Although the etiology and expression of psychiatric disorders are complex, mammals show
biologically preserved behavioral and neurobiological responses to valent stimuli which …
biologically preserved behavioral and neurobiological responses to valent stimuli which …
Rodent tests of depression and anxiety: Construct validity and translational relevance
Behavioral testing constitutes the primary method to measure the emotional states of
nonhuman animals in preclinical research. Emerging as the characteristic tool of the …
nonhuman animals in preclinical research. Emerging as the characteristic tool of the …
Anhedonia as a central factor in depression: Neural mechanisms revealed from preclinical to clinical evidence
Anhedonia is one of the core symptoms of major depressive disorder (MDD), which is often
inadequately treated by traditional antidepressants. The modern framework of anhedonia …
inadequately treated by traditional antidepressants. The modern framework of anhedonia …
Making sense of rodent models of anhedonia
A markedly reduced interest or pleasure in activities previously considered pleasurable is a
main symptom in mood disorder and psychosis and is often present in other psychiatric …
main symptom in mood disorder and psychosis and is often present in other psychiatric …
Defining biotypes for depression and anxiety based on large‐scale circuit dysfunction: A theoretical review of the evidence and future directions for clinical translation
Complex emotional, cognitive and self‐reflective functions rely on the activation and
connectivity of large‐scale neural circuits. These circuits offer a relevant scale of focus for …
connectivity of large‐scale neural circuits. These circuits offer a relevant scale of focus for …
Peril and pleasure: An RDOC‐inspired examination of threat responses and reward processing in anxiety and depression
As a step toward addressing limitations in the current psychiatric diagnostic system, the
National Institute of Mental Health recently developed the Research Domain Criteria (RDoC) …
National Institute of Mental Health recently developed the Research Domain Criteria (RDoC) …