Functional status is considered the main determinant of healthy aging. Impairment in
skeletal muscle and the cardiovascular system, two interrelated systems, results in …

Several biomarkers have been proposed to identify frailty, a multisystemic age-related
syndrome. However, the complex pathophysiology and the absence of a consensus on a …

Biological aging, characterized by changes in metabolism and physicochemical properties
of cells, has an impact on public health. Environment and lifestyle, including factors like diet …

Metformin is a widely accepted first-line hypoglycemic agent in current clinical practice, and
it has been applied to the clinic for more than 60 years. Recently, researchers have …

The composition of skeletal muscle fiber types affects the quality of livestock meat and
human athletic performance and health. L-arginine (Arg), a semi-essential amino acid, has …

Background The incidence of periodontitis is high in older individuals. However, its impact
on multi-organ frailty remains unclear. We developed mouse models with varying severity …

Treatments are lacking for sarcopenia, which is an age‐related disease characterized by
loss of skeletal muscle mass, strength, and/or physical performance. Icariin is a …