Cardiac arrhythmias are among the leading causes of mortality. They often arise from
alterations in the electrophysiological properties of cardiac cells and their underlying ionic …

The complexity of cardiac electrophysiology, involving dynamic changes in numerous
components across multiple spatial (from ion channel to organ) and temporal (from …

Background: Current ablation therapy for atrial fibrillation is suboptimal, and long-term
response is challenging to predict. Clinical trials identify bedside properties that provide only …

Cardiac electrophysiology models are among the most mature and well‐studied
mathematical models of biological systems. This maturity is bringing new challenges as …

Physiological variability manifests itself via differences in physiological function between
individuals of the same species, and has crucial implications in disease progression and …

Mechano‐electric regulations (MER) play an important role in the maintenance of cardiac
performance. Mechano‐calcium and mechano‐electric feedback (MCF and MEF) pathways …

Key points• Previous studies have shown that atrial electrical properties are altered
(remodelled) by atrial fibrillation (AF) and that the recurrence of AF is high following …

Aims Human atrial electrophysiology exhibits high inter-subject variability in both sinus
rhythm (SR) and chronic atrial fibrillation (cAF) patients. Variability is however rarely …

The traditional cardiac model-building paradigm involves constructing a composite model
using data collected from many cells. Equations are derived for each relevant cellular …

Atrial arrhythmias, and specifically atrial fibrillation (AF), induce rapid and irregular activation
patterns that appear on the torso surface as abnormal P-waves in electrocardiograms and …