Frequency locked whispering evanescent resonator (FLOWER) for biochemical sensing applications

S Suebka, A Gin, J Su - Nature Protocols, 2025 - nature.com
Sensitive, rapid and label-free biochemical sensors are needed for many applications. In
this protocol, we describe biochemical detection using FLOWER (frequency locked optical …

Single-molecule optofluidic microsensor with interface whispering gallery modes

XC Yu, SJ Tang, W Liu, Y Xu, Q Gong, YL Chen… - Proceedings of the …, 2022 - pnas.org
Label-free sensors are highly desirable for biological analysis and early-stage disease
diagnosis. Optical evanescent sensors have shown extraordinary ability in label-free …

Ultra-high-Q free-space coupling to microtoroid resonators

S Suebka, E McLeod, J Su - Light: Science & Applications, 2024 - nature.com
Whispering gallery mode (WGM) microtoroid resonators are one of the most sensitive
biochemical sensors in existence, capable of detecting single molecules. The main barrier …

Low part-per-trillion, humidity resistant detection of nitric oxide using microtoroid optical resonators

Y Xu, AM Stanko, CS Cerione, TD Lohrey… - … Applied Materials & …, 2024 - ACS Publications
The nitric oxide radical plays pivotal roles in physiological as well as atmospheric contexts.
Although the detection of dissolved nitric oxide in vivo has been widely explored, highly …

High-Q WGM microcavity-based optofluidic sensor technologies for biological analysis

Z Wang, B Zhou, AP Zhang - Biomicrofluidics, 2024 - pubs.aip.org
High-quality-factor (Q) optical microcavities have attracted extensive interest due to their
unique ability to confine light for resonant circulation at the micrometer scale. Particular …

Steviol rebaudiosides bind to four different sites of the human sweet taste receptor (T1R2/T1R3) complex explaining confusing experiments

S Hao, B Guthrie, SK Kim, S Balanda… - Communications …, 2024 - nature.com
Sucrose provides both sweetness and energy by binding to both Venus flytrap domains
(VFD) of the heterodimeric sweet taste receptor (T1R2/T1R3). In contrast, non-caloric …

Methotrexate inhibits the binding of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) receptor binding domain to the host-cell angiotensin …

SK Kim, S Suebka, A Gin, PD Nguyen… - ACS Pharmacology & …, 2024 - ACS Publications
As the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus mutates,
finding effective drugs becomes more challenging. In this study, we use ultrasensitive …

Part-per-trillion trace selective gas detection using frequency locked whispering-gallery mode microtoroids

C Li, T Lohrey, PD Nguyen, Z Min, Y Tang… - … Applied Materials & …, 2022 - ACS Publications
Rapid detection of toxic and hazardous gases at trace concentrations plays a vital role in
industrial, battlefield, and laboratory scenarios. Of interest are both sensitive as well as …

Label-free, real-time monitoring of membrane binding events at zeptomolar concentrations using frequency-locked optical microresonators

A Gin, PD Nguyen, JE Melzer, C Li, H Strzelinski… - Nature …, 2024 - nature.com
G-protein coupled receptors help regulate cellular function and communication, and are
targets of small molecule drug discovery efforts. Conventional techniques to probe these …

Single 5-nm quantum dot detection via microtoroid optical resonator photothermal microscopy

S Hao, S Suebka, J Su - Light: Science & Applications, 2024 - nature.com
Label-free detection techniques for single particles and molecules play an important role in
basic science, disease diagnostics, and nanomaterial investigations. While fluorescence …