CD8 T cell exhaustion during chronic viral infection and cancer
LM McLane, MS Abdel-Hakeem… - Annual review of …, 2019 - annualreviews.org
Exhausted CD8 T (Tex) cells are a distinct cell lineage that arise during chronic infections
and cancers in animal models and humans. Tex cells are characterized by progressive loss …
and cancers in animal models and humans. Tex cells are characterized by progressive loss …
Targeting immunosuppressive adenosine in cancer
Despite the success of anti-programmed cell death protein 1 (PD1), anti-PD1 ligand 1
(PDL1) and anti-cytotoxic T lymphocyte antigen 4 (CTLA4) therapies in advanced cancer, a …
(PDL1) and anti-cytotoxic T lymphocyte antigen 4 (CTLA4) therapies in advanced cancer, a …
Pan-cancer single-cell landscape of tumor-infiltrating T cells
INTRODUCTION Cancer immunotherapies that target tumor-specific T cells have benefited
many cancer patients, but the clinical efficacy varies greatly among different cancer types …
many cancer patients, but the clinical efficacy varies greatly among different cancer types …
Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications
INTRODUCTION Many patients with coronavirus disease 2019 (COVID-19), caused by
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, present with …
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, present with …
[HTML][HTML] Defining T cell states associated with response to checkpoint immunotherapy in melanoma
Treatment of cancer has been revolutionized by immune checkpoint blockade therapies.
Despite the high rate of response in advanced melanoma, the majority of patients succumb …
Despite the high rate of response in advanced melanoma, the majority of patients succumb …
Hypoxia drives CD39-dependent suppressor function in exhausted T cells to limit antitumor immunity
PDA Vignali, K DePeaux, MLJ Watson, C Ye… - Nature …, 2023 - nature.com
CD8+ T cells are critical for elimination of cancer cells. Factors within the tumor
microenvironment (TME) can drive these cells to a hypofunctional state known as …
microenvironment (TME) can drive these cells to a hypofunctional state known as …
LRRC15+ myofibroblasts dictate the stromal setpoint to suppress tumour immunity
AT Krishnamurty, JA Shyer, M Thai, V Gandham… - Nature, 2022 - nature.com
Recent single-cell studies of cancer in both mice and humans have identified the
emergence of a myofibroblast population specifically marked by the highly restricted leucine …
emergence of a myofibroblast population specifically marked by the highly restricted leucine …
T-cell invigoration to tumour burden ratio associated with anti-PD-1 response
AC Huang, MA Postow, RJ Orlowski, R Mick… - Nature, 2017 - nature.com
Despite the success of monotherapies based on blockade of programmed cell death 1 (PD-
1) in human melanoma, most patients do not experience durable clinical benefit. Pre …
1) in human melanoma, most patients do not experience durable clinical benefit. Pre …
Bystander CD8+ T cells are abundant and phenotypically distinct in human tumour infiltrates
Various forms of immunotherapy, such as checkpoint blockade immunotherapy, are proving
to be effective at restoring T cell-mediated immune responses that can lead to marked and …
to be effective at restoring T cell-mediated immune responses that can lead to marked and …
A transcriptionally and functionally distinct PD-1+ CD8+ T cell pool with predictive potential in non-small-cell lung cancer treated with PD-1 blockade
Evidence from mouse chronic viral infection models suggests that CD8+ T cell subsets
characterized by distinct expression levels of the receptor PD-1 diverge in their state of …
characterized by distinct expression levels of the receptor PD-1 diverge in their state of …