The founding in 1965 of what is now called the Cambridge Structural Database (CSD) has
reaped dividends in numerous and diverse areas of chemical research. Each of the million …

The computational method is widely used in the field of drug design as well as discovery. It
aids the drug discovery and design process by making the procedure faster while also …

Through this extensive structure–property study we show that critical micelle concentration
correlates with self‐associative hydrogen bond complex formation constant, when combined …

Complexation reactions of palladium (II) nitrate with a set of 3-pyridyl appended
nonchelating bidentate ligands possessing regioisomeric phenylene-diurea functionalities …

Kinases have proven valuable targets in successful cancer drug discovery projects, but not
yet for malignant brain tumors where type-II inhibition of cyclin-dependent kinase 5 (CDK5) …

Cyclophilins (Cyps) are a major family of drug targets that are challenging to prosecute with
small molecules because the shallow nature and high degree of conservation of the active …

Ureas are an important functional group in small molecule drugs as well as having wider
applications in organic chemistry. Understanding of their conformation is of critical …

Antimitotic agents are one of the more successful types of anticancer drugs, but they suffer
from toxicity and resistance. The application of approved drugs to new indications (ie, drug …

Herein we present the synthesis of two ligands containing two di (2-picolyl) amine (DPA)
units linked by either a 1, 1′-(pyridine-2, 6-diyl) bis (3-ethylurea)(L1) or a 1, 1′-(1, 3 …

Medulloblastoma–highly aggressive and heterogeneous tumours of the cerebellum–
account for 15–20% of all childhood brain tumours, and are the most common high-grade …