The establishing of the first cancer models created a new perspective on the identification
and evaluation of new anti-cancer therapies in preclinical studies. Patient-derived xenograft …

Lung cancer causes the largest number of cancer-related deaths in the world. Most (85%) of
lung cancers are classified as non-small-cell lung cancer (NSCLC) and small-cell lung …

Establishing an appropriate preclinical model is crucial for translational cancer research.
The most common way that has been adopted by far is grafting cancer cell lines, derived …

Cancer is a major stress for public well‐being and is the most dreadful disease. The models
used in the discovery of cancer treatment are continuously changing and extending toward …

Progress in oncology drug development has been hampered by a lack of preclinical models
that reliably predict clinical activity of novel compounds in cancer patients. In an effort to …

Metastatic dissemination is the leading cause of death in cancer patients, which is
particularly evident for high-risk sarcomas such as Ewing sarcoma, osteosarcoma, and …

Standardized and reproducible preclinical models that recapitulate the dynamics of prostate
cancer are urgently needed. We established a bank of transplantable patient-derived …

Purpose: It was the aim of our study to establish an extensive panel of non-small cell lung
cancer (NSCLC) xenograft models useful for the testing of novel compounds and for the …

Mouse cancer models have consistently been used to qualify new anticancer drugs in the
development of human clinical trials. Rodent tumour models currently being used and which …

Objective Metastasis is the most common cause of death of prostate cancer patients.
Identification of specific metastasis biomarkers and novel therapeutic targets is considered …