Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism
Secreted extracellular vesicles (EVs) influence the tumor microenvironment and promote
distal metastasis. Here we analyzed the involvement of melanoma-secreted EVs in lymph …
distal metastasis. Here we analyzed the involvement of melanoma-secreted EVs in lymph …
Genomic and immune landscape of metastatic pheochromocytoma and paraganglioma
The mechanisms triggering metastasis in pheochromocytoma/paraganglioma are unknown,
hindering therapeutic options for patients with metastatic tumors (mPPGL). Herein we show …
hindering therapeutic options for patients with metastatic tumors (mPPGL). Herein we show …
Stratification of radiosensitive brain metastases based on an actionable S100A9/RAGE resistance mechanism
Whole-brain radiotherapy (WBRT) is the treatment backbone for many patients with brain
metastasis; however, its efficacy in preventing disease progression and the associated …
metastasis; however, its efficacy in preventing disease progression and the associated …
A mild increase in nutrient signaling to mTORC1 in mice leads to parenchymal damage, myeloid inflammation and shortened lifespan
A Ortega-Molina, C Lebrero-Fernández, A Sanz… - Nature Aging, 2024 - nature.com
The mechanistic target of rapamycin complex 1 controls cellular anabolism in response to
growth factor signaling and to nutrient sufficiency signaled through the Rag GTPases …
growth factor signaling and to nutrient sufficiency signaled through the Rag GTPases …
Exploiting oxidative phosphorylation to promote the stem and immunoevasive properties of pancreatic cancer stem cells
Pancreatic ductal adenocarcinoma (PDAC), the fourth leading cause of cancer death, has a
5-year survival rate of approximately 7–9%. The ineffectiveness of anti-PDAC therapies is …
5-year survival rate of approximately 7–9%. The ineffectiveness of anti-PDAC therapies is …
Saa3 is a key mediator of the protumorigenic properties of cancer-associated fibroblasts in pancreatic tumors
Pancreatic ductal adenocarcinoma (PDAC) is characterized by the presence of abundant
desmoplastic stroma primarily composed of cancer-associated fibroblasts (CAFs). It is …
desmoplastic stroma primarily composed of cancer-associated fibroblasts (CAFs). It is …
Midkine rewires the melanoma microenvironment toward a tolerogenic and immune-resistant state
An open question in aggressive cancers such as melanoma is how malignant cells can shift
the immune system to pro-tumorigenic functions. Here we identify midkine (MDK) as a …
the immune system to pro-tumorigenic functions. Here we identify midkine (MDK) as a …
ISG15 and ISGylation is required for pancreatic cancer stem cell mitophagy and metabolic plasticity
Pancreatic cancer stem cells (PaCSCs) drive pancreatic cancer tumorigenesis,
chemoresistance and metastasis. While eliminating this subpopulation of cells would …
chemoresistance and metastasis. While eliminating this subpopulation of cells would …
Targeting cancer stem cell OXPHOS with tailored ruthenium complexes as a new anti-cancer strategy
Background Previous studies by our group have shown that oxidative phosphorylation
(OXPHOS) is the main pathway by which pancreatic cancer stem cells (CSCs) meet their …
(OXPHOS) is the main pathway by which pancreatic cancer stem cells (CSCs) meet their …
Global transcriptomic profiling of the bone marrow stromal microenvironment during postnatal development, aging, and inflammation
Bone marrow (BM) stromal cells provide the regulatory framework for hematopoiesis and
contribute to developmental stage-specific niches, such as those preserving hematopoietic …
contribute to developmental stage-specific niches, such as those preserving hematopoietic …