Cancer is the second leading cause of death globally and its incidence and mortality are
rapidly increasing worldwide. The dynamic interaction of immune cells and tumor cells …

In the present review, we will discuss the recent advances in the understanding of the role of
histamine and histamine receptors in cancer biology. The controversial role of the …

Breast cancer is the most common cancer among women and is considered a developed
country disease. Moreover, is a heterogenous disease, existing different types and stages of …

High levels of histamine and histamine receptors (HRs), including H1R~ H4R, are found in
many different types of tumor cells and cells in the tumor microenvironment, suggesting their …

Among mouse mammary tumor models, syngeneic cell lines present an advantage for the
study of immune response. However, few of these models are well characterized. The tumor …

Histamine exerts potent modulatory impacts on the cells of innate-[including neutrophils,
monocytes, macrophages, dendritic cells (DCs), natural killer (NK) cells and NKT cells] and …

Mast cells are important sentinel cells in host defense against infection and major effector
cells in allergic disease. The role of these cells in cancer settings has been widely debated …

Psychiatric alterations are often found in patients with breast cancer even before the
initiation of adjuvant therapy, resulting in a poor quality of life. It has become accepted that …

Mast cells are well known to be activated via cross-linking of immunoglobulins bound to
surface receptors. They are also recognized as key initiators and regulators of both innate …

Breast cancer is the most common malignancy in women, and despite the development of
new treatment methods and the decreasing mortality rate in recent years, one of the clinical …