Multicomponent reactions (MCRs) are one-pot reactions employing more than two starting
materials, for example, 3, 4,..., 7, where most of the atoms of the starting materials are …

Multicomponent reactions (MCRs) are generally defined as reactions where more than two
staring materials react to form a product, incorporating essentially all of the atoms of the …

The quinoline scaffold is prevalent in a variety of pharmacologically active synthetic and
natural compounds. The discovery of chloroquine, the most famous drug containing this …

Multicomponent reactions are flexible reactions for the rapid generation of complex
molecules with often biologically relevant scaffold structures. Combined with the ease of …

INTRODUCTION The four-component Ugi reaction (Ugi-4CR) assembles peptide-like α-
acylaminoamides through one-pot reaction of a carbonyl compound, an amine, an acid, and …

This review describes recent advances in the application of isocyanide-based
multicomponent reactions (IMCRs) in drug discovery and summarizes the various …

EGFR and VEGFR-2 represent promising targets for cancer treatment as they are very
important in tumor development as well as in angiogenesis and metastasis. In this work, 6 …

Malaria has been a human health concern ever since the dawn of mankind, but despite the
huge struggles made to date to fight this infection, in 2012 over half a million people were …

A new class of 4-aminoquinoline derivatives based on the natural product isatin scaffold
were designed and synthesized for biological evaluation against three strains of the malaria …

A short history of hybrid molecules based on aminoquinolines gave interesting and
important information useful for organic and medicinal chemistry, which are deeply involved …