Review The Cancer Genome Atlas (TCGA): an immeasurable source of knowledge
The Cancer Genome Atlas (TCGA) is a public funded project that aims to catalogue and
discover major cancer-causing genomic alterations to create a comprehensive “atlas” of …
discover major cancer-causing genomic alterations to create a comprehensive “atlas” of …
A uniform system for the annotation of vertebrate microRNA genes and the evolution of the human microRNAome
Although microRNAs (miRNAs) are among the most intensively studied molecules of the
past 20 years, determining what is and what is not a miRNA has not been straightforward …
past 20 years, determining what is and what is not a miRNA has not been straightforward …
Neuroblastoma: molecular pathogenesis and therapy
CU Louis, JM Shohet - Annual review of medicine, 2015 - annualreviews.org
Neuroblastoma is a developmental tumor of young children arising from the embryonic
sympathoadrenal lineage of the neural crest. Neuroblastoma is the primary cause of death …
sympathoadrenal lineage of the neural crest. Neuroblastoma is the primary cause of death …
3′ UTR shortening represses tumor-suppressor genes in trans by disrupting ceRNA crosstalk
Widespread mRNA 3′ UTR shortening through alternative polyadenylation promotes tumor
growth in vivo. A prevailing hypothesis is that it induces proto-oncogene expression in cis …
growth in vivo. A prevailing hypothesis is that it induces proto-oncogene expression in cis …
[HTML][HTML] SNHG16 is regulated by the Wnt pathway in colorectal cancer and affects genes involved in lipid metabolism
It is well established that lncRNAs are aberrantly expressed in cancer where they have been
shown to act as oncogenes or tumor suppressors. RNA profiling of 314 colorectal …
shown to act as oncogenes or tumor suppressors. RNA profiling of 314 colorectal …
Unique somatic and malignant expression patterns implicate PIWI-interacting RNAs in cancer-type specific biology
Abstract Human PIWI-interacting RNAs (piRNAs) are known to be expressed in germline
cells, functionally silencing LINEs and SINEs. Their expression patterns in somatic tissues …
cells, functionally silencing LINEs and SINEs. Their expression patterns in somatic tissues …
[HTML][HTML] MicroRNAs in cancer: a historical perspective on the path from discovery to therapy
Recent progress in microRNA (miRNA) therapeutics has been strongly dependent on
multiple seminal discoveries in the area of miRNA biology during the past two decades. In …
multiple seminal discoveries in the area of miRNA biology during the past two decades. In …
Diagnostic value of a plasma microRNA signature in gastric cancer: a microRNA expression analysis
X Zhou, W Zhu, H Li, W Wen, W Cheng, F Wang… - Scientific reports, 2015 - nature.com
The differential expression of microRNAs (miRNAs) in plasma of gastric cancer (GC)
patients may serve as a diagnostic biomarker. A total of 33 miRNAs were identified through …
patients may serve as a diagnostic biomarker. A total of 33 miRNAs were identified through …
Transcriptional cofactors Ski and SnoN are major regulators of the TGF-β/Smad signaling pathway in health and disease
AC Tecalco-Cruz, DG Ríos-López… - Signal transduction and …, 2018 - nature.com
The transforming growth factor-β (TGF-β) family plays major pleiotropic roles by regulating
many physiological processes in development and tissue homeostasis. The TGF-β signaling …
many physiological processes in development and tissue homeostasis. The TGF-β signaling …
USP13 functions as a tumor suppressor by blocking the NF-kB-mediated PTEN downregulation in human bladder cancer
X Man, C Piao, X Lin, C Kong, X Cui, Y Jiang - Journal of Experimental & …, 2019 - Springer
Background USP13 has been reported to be involved in the tumorigenesis of human
cancers, however, its functional role and regulatory mechanisms in bladder cancer (BC) …
cancers, however, its functional role and regulatory mechanisms in bladder cancer (BC) …