Oxidative stress and inflammation in diabetic nephropathy: role of polyphenols

Q **, T Liu, Y Qiao, D Liu, L Yang, H Mao… - Frontiers in …, 2023 - frontiersin.org
Diabetic nephropathy (DN) often leads to end-stage renal disease. Oxidative stress
demonstrates a crucial act in the onset and progression of DN, which triggers various …

[HTML][HTML] Stress, epigenetics, and aging: unraveling the intricate crosstalk

Z Wu, J Qu, W Zhang, GH Liu - Molecular Cell, 2024 - cell.com
Aging, as a complex process involving multiple cellular and molecular pathways, is known to
be exacerbated by various stresses. Because responses to these stresses, such as oxidative …

Mitochondria: It is all about energy

A Casanova, A Wevers, S Navarro-Ledesma… - Frontiers in …, 2023 - frontiersin.org
Mitochondria play a key role in both health and disease. Their function is not limited to
energy production but serves multiple mechanisms varying from iron and calcium …

The potential benefits of quercetin for brain health: a review of anti-inflammatory and neuroprotective mechanisms

MC Chiang, TY Tsai, CJ Wang - International Journal of Molecular …, 2023 - mdpi.com
Neuroinflammation is a critical factor in develo** and progressing numerous brain
diseases, including neurodegenerative diseases. Chronic or excessive neuroinflammation …

Fungal endophytes: Microfactories of novel bioactive compounds with therapeutic interventions; A comprehensive review on the biotechnological developments in the …

A Gupta, V Meshram, M Gupta, S Goyal, KA Qureshi… - Biomolecules, 2023 - mdpi.com
The seminal discovery of paclitaxel from endophytic fungus Taxomyces andreanae was a
milestone in recognizing the immense potential of endophytic fungi as prolific producers of …

[HTML][HTML] Nrf2 signaling pathway: current status and potential therapeutic targetable role in human cancers

L Lin, Q Wu, F Lu, J Lei, Y Zhou, Y Liu, N Zhu… - Frontiers in …, 2023 - frontiersin.org
Cancer is a borderless global health challenge that continues to threaten human health.
Studies have found that oxidative stress (OS) is often associated with the etiology of many …

Pharmacological and molecular insight on the cardioprotective role of apigenin

SD Thomas, NK Jha, SK Jha, B Sadek, S Ojha - Nutrients, 2023 - mdpi.com
Apigenin is a naturally occurring dietary flavonoid found abundantly in fruits and vegetables.
It possesses a wide range of biological properties that exert antioxidant, anti-inflammatory …

Recent advancement in bioeffect, metabolism, stability, and delivery systems of apigenin, a natural flavonoid compound: Challenges and perspectives

P Chen, F Chen, ZL Guo, J Lei, B Zhou - Frontiers in Nutrition, 2023 - frontiersin.org
Apigenin is a bioflavonoid compound that is widely present in dietary plant foods and
possesses biological activities that protect against immune, cardiovascular, and …

Cellular senescence of renal tubular epithelial cells in renal fibrosis

JQ Zhang, YY Li, XY Zhang, ZH Tian, C Liu… - Frontiers in …, 2023 - frontiersin.org
Renal fibrosis (RF) is the common pathological manifestation of virtually all chronic kidney
diseases (CKD) and one of the major causes of end-stage renal disease (ESRD), but the …

Hypoglycemic medicines in the treatment of Alzheimer's disease: Pathophysiological links between AD and glucose metabolism

Y Wang, H Hu, X Liu, X Guo - Frontiers in Pharmacology, 2023 - frontiersin.org
Alzheimer's Disease (AD) is a global chronic disease in adults with beta-amyloid (Aβ)
deposits and hyperphosphorylated tau protein as the pathologic characteristics. Although …